Rapidly degraded terpolymers of DL‐lactide, glycolide, and ϵ‐caprolactone with increased hydrophilicity by copolymerization with polyethers

Amarpreet S. Sawhney, Jeffrey A. Hubbell

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Abstract

A terpolymeric composition of 60% glycolide, 30% dl-lactide, and 10% ε-caprolactone, which exhibited a half-life of 17 days, was selected for further investigation. The hydrophilicity of this material was increased by performing the polymerization in the presence of a polyether prepolymer, Pluronic F-68, with the motivation of concomitantly reducing cell and tissue adhesion. An increase in the hydrophilicity of the material was apparent from contact angle measurements. Copolymerization with the prepolymer also resulted in a stronger and partly crystalline material which was mechanically stable at physiological temperature in water. A slight increase was observed in the half-life of the polymer relative to the base polymer due to the presence of the prepolymer.

Original languageEnglish (US)
Pages (from-to)1397-1411
Number of pages15
JournalJournal of Biomedical Materials Research
Volume24
Issue number10
DOIs
StatePublished - Oct 1990

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ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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