Rapidly degraded terpolymers of dl-lactide, glycolide, and ε-caprolactone with increased hydrophilicity by copolymerization with polyethers

A. S. Sawhney, J. A. Hubbell

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

A terpolymeric composition of 60% glycolide, 30% dl-lactide, and 10% ε-caprolactone, which exhibited a half-life of 17 days, was selected for further investigation. The hydrophilicity of this material was increased by performing the polymerization in the presence of a polyether prepolymer, Pluronic F-68, with the motivation of concomitantly reducing cell and tissue adhesion. An increase in the hydrophilicity of the material was apparent from contact angle measurements. Copolymerization with the prepolymer also resulted in a stronger and partly crystalline material which was mechanically stable at physiological temperature in water. A slight increase was observed in the half-life of the polymer relative to the base polymer due to the presence of the prepolymer.

Original languageEnglish
Pages (from-to)1397-1411
Number of pages15
JournalJournal of Biomedical Materials Research
Volume24
Issue number10
DOIs
StatePublished - Oct 1 1990
Externally publishedYes

Fingerprint

Terpolymers
Polyethers
Hydrophilicity
Copolymerization
Polymers
Poloxamer
Angle measurement
Contact angle
Adhesion
Polymerization
Tissue
Crystalline materials
Water
Chemical analysis
Temperature
caprolactone
dilactide

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this

Rapidly degraded terpolymers of dl-lactide, glycolide, and ε-caprolactone with increased hydrophilicity by copolymerization with polyethers. / Sawhney, A. S.; Hubbell, J. A.

In: Journal of Biomedical Materials Research, Vol. 24, No. 10, 01.10.1990, p. 1397-1411.

Research output: Contribution to journalArticle

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