Rapid Species Determination of Nocardia Keratitis Using Pyrosequencing Technology

Anat Galor, Gerri S. Hall, Gary W. Procop, Marion Tuohy, Michael E. Millstein, Bennie H. Jeng

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Purpose: To describe a new technique, pyrosequencing, which allows for the rapid identification of Mycobacterium and Nocardia species. Design: Interventional case report. Methods: The medical records of a patient presenting with an infectious keratitis were reviewed. Results: A case of Nocardia abscessus/arthrititis/asiatica keratitis was diagnosed in a young individual with the aid of pyrosequencing technology. Based on presumed antibiotic sensitivities, therapy with topical trimethoprim-sulfamethoxazole eyedrops was initiated, and the infection was cleared rapidly with minimal residual scarring. Conclusions: Pyrosequencing may be a useful tool in aiding the rapid diagnosis and treatment of ocular infections caused by slow-growing pathogens.

Original languageEnglish (US)
Pages (from-to)182-183
Number of pages2
JournalAmerican journal of ophthalmology
Issue number1
StatePublished - Jan 2007
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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