Rapid involution of large cardiac rhabdomyomas with everolimus therapy.

Ashish Garg; Sudheer Gorla; Richard Kardon; Sethuraman Swaminathan

doi:https://doi.org/10.1177/2150135118822711

Rapid involution of large cardiac rhabdomyomas with everolimus therapy.

Ashish Garg, Sudheer Gorla, Richard Kardon, Sethuraman Swaminathan

Pediatrics

Research output: Contribution to journal › Article › peer-review

Abstract

Rhabdomyoma of the fetal heart is a rare disease accounting for about 1% of all fetal cardiac structural anomalies. They are often found in association with tuberous sclerosis complex. Large cardiac rhabdomyomas can compromise the cardiac function. We report a case of multiple large rhabdomyomas of the right and left ventricles, affecting the cardiac function, which was successfully treated with the chemotherapeutic and immunosuppressive medication everolimus, in a neonate with genetically confirmed tuberous sclerosis complex with multisystem manifestations. There was rapid involution of the tumors in response to everolimus therapy in this infant.

Original language	English (US)
Pages (from-to)	1-3
Number of pages	3
Journal	World Journal for Pediatric and Congenital Hearth Surgery
DOIs	https://doi.org/10.1177/2150135118822711
State	Published - May 10 2019

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title = "Rapid involution of large cardiac rhabdomyomas with everolimus therapy.",

abstract = "Rhabdomyoma of the fetal heart is a rare disease accounting for about 1% of all fetal cardiac structural anomalies. They are often found in association with tuberous sclerosis complex. Large cardiac rhabdomyomas can compromise the cardiac function. We report a case of multiple large rhabdomyomas of the right and left ventricles, affecting the cardiac function, which was successfully treated with the chemotherapeutic and immunosuppressive medication everolimus, in a neonate with genetically confirmed tuberous sclerosis complex with multisystem manifestations. There was rapid involution of the tumors in response to everolimus therapy in this infant.",

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AB - Rhabdomyoma of the fetal heart is a rare disease accounting for about 1% of all fetal cardiac structural anomalies. They are often found in association with tuberous sclerosis complex. Large cardiac rhabdomyomas can compromise the cardiac function. We report a case of multiple large rhabdomyomas of the right and left ventricles, affecting the cardiac function, which was successfully treated with the chemotherapeutic and immunosuppressive medication everolimus, in a neonate with genetically confirmed tuberous sclerosis complex with multisystem manifestations. There was rapid involution of the tumors in response to everolimus therapy in this infant.

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DO - https://doi.org/10.1177/2150135118822711

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