Rapid infusion with valproate sodium is well tolerated in patients with epilepsy

J. W. Wheless, B. R. Vazquez, A. M. Kanner, R. E. Ramsay, L. Morton, John M. Pellock

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Many IV antiepileptic drugs administered in emergency situations to patients with prolonged seizures have serious adverse effects. For this reason, the authors conducted a multicenter, open-label, prospective, dose-escalation study of IV valproate sodium administered to patients with epilepsy at rates of infusion of up to 6 mg/kg/minute and doses of up to 30 mg/kg. Valproate sodium had no clinically significant negative effects on blood pressure and pulse rate and caused only mild-to-moderate, reversible adverse events.

Original languageEnglish (US)
Pages (from-to)1507-1508
Number of pages2
JournalNeurology
Volume63
Issue number8
DOIs
StatePublished - Oct 26 2004
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Rapid infusion with valproate sodium is well tolerated in patients with epilepsy'. Together they form a unique fingerprint.

Cite this