Rapid infusion with valproate sodium is well tolerated in patients with epilepsy

J. W. Wheless, B. R. Vazquez, Andres M Kanner, R. E. Ramsay, L. Morton, John M. Pellock

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Many IV antiepileptic drugs administered in emergency situations to patients with prolonged seizures have serious adverse effects. For this reason, the authors conducted a multicenter, open-label, prospective, dose-escalation study of IV valproate sodium administered to patients with epilepsy at rates of infusion of up to 6 mg/kg/minute and doses of up to 30 mg/kg. Valproate sodium had no clinically significant negative effects on blood pressure and pulse rate and caused only mild-to-moderate, reversible adverse events.

Original languageEnglish (US)
Pages (from-to)1507-1508
Number of pages2
JournalNeurology
Volume63
Issue number8
StatePublished - Oct 26 2004
Externally publishedYes

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Valproic Acid
Epilepsy
Anticonvulsants
Seizures
Emergencies
Heart Rate
Blood Pressure

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Wheless, J. W., Vazquez, B. R., Kanner, A. M., Ramsay, R. E., Morton, L., & Pellock, J. M. (2004). Rapid infusion with valproate sodium is well tolerated in patients with epilepsy. Neurology, 63(8), 1507-1508.

Rapid infusion with valproate sodium is well tolerated in patients with epilepsy. / Wheless, J. W.; Vazquez, B. R.; Kanner, Andres M; Ramsay, R. E.; Morton, L.; Pellock, John M.

In: Neurology, Vol. 63, No. 8, 26.10.2004, p. 1507-1508.

Research output: Contribution to journalArticle

Wheless, JW, Vazquez, BR, Kanner, AM, Ramsay, RE, Morton, L & Pellock, JM 2004, 'Rapid infusion with valproate sodium is well tolerated in patients with epilepsy', Neurology, vol. 63, no. 8, pp. 1507-1508.
Wheless JW, Vazquez BR, Kanner AM, Ramsay RE, Morton L, Pellock JM. Rapid infusion with valproate sodium is well tolerated in patients with epilepsy. Neurology. 2004 Oct 26;63(8):1507-1508.
Wheless, J. W. ; Vazquez, B. R. ; Kanner, Andres M ; Ramsay, R. E. ; Morton, L. ; Pellock, John M. / Rapid infusion with valproate sodium is well tolerated in patients with epilepsy. In: Neurology. 2004 ; Vol. 63, No. 8. pp. 1507-1508.
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