Abstract
The co-expression of B7.1 (CD80) and intercellular adhesion molecule (ICAM)-1 (CD54) on tumor cells can induce tumor immunity and immunological memory. We show here that the non-immunogenic tumor lines Lewis lung carcinoma and B16F10 melanoma, co-transfected with B7.1 and ICAM-1, induced cytotoxic levels of membrane tumor necrosis factor (TNF) on naive syngeneic T cells within 24 h. Membrane TNF expression, primarily on CD4 cells, was responsible for tumor cell lysis by naive spleen cells and could be completely abolished by anti-TNF antiserum. It is suggested that the strong induction of TNF cytotoxicity may be important in the establishment of tumor immunity.
| Original language | English |
|---|---|
| Pages (from-to) | 2160-2164 |
| Number of pages | 5 |
| Journal | European Journal of Immunology |
| Volume | 26 |
| Issue number | 9 |
| State | Published - Sep 22 1996 |
| Externally published | Yes |
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Keywords
- CD4 cells
- Tumor immunity
ASJC Scopus subject areas
- Immunology
Cite this
Rapid induction of tumor necrosis factor cytotoxicity in naive splenic T cells by simultaneous CD80 (B7.1) and CD54 (ICAM-1) co-stimulation. / Nishio, Makoto; Podack, Eckhard R.
In: European Journal of Immunology, Vol. 26, No. 9, 22.09.1996, p. 2160-2164.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Rapid induction of tumor necrosis factor cytotoxicity in naive splenic T cells by simultaneous CD80 (B7.1) and CD54 (ICAM-1) co-stimulation
AU - Nishio, Makoto
AU - Podack, Eckhard R.
PY - 1996/9/22
Y1 - 1996/9/22
N2 - The co-expression of B7.1 (CD80) and intercellular adhesion molecule (ICAM)-1 (CD54) on tumor cells can induce tumor immunity and immunological memory. We show here that the non-immunogenic tumor lines Lewis lung carcinoma and B16F10 melanoma, co-transfected with B7.1 and ICAM-1, induced cytotoxic levels of membrane tumor necrosis factor (TNF) on naive syngeneic T cells within 24 h. Membrane TNF expression, primarily on CD4 cells, was responsible for tumor cell lysis by naive spleen cells and could be completely abolished by anti-TNF antiserum. It is suggested that the strong induction of TNF cytotoxicity may be important in the establishment of tumor immunity.
AB - The co-expression of B7.1 (CD80) and intercellular adhesion molecule (ICAM)-1 (CD54) on tumor cells can induce tumor immunity and immunological memory. We show here that the non-immunogenic tumor lines Lewis lung carcinoma and B16F10 melanoma, co-transfected with B7.1 and ICAM-1, induced cytotoxic levels of membrane tumor necrosis factor (TNF) on naive syngeneic T cells within 24 h. Membrane TNF expression, primarily on CD4 cells, was responsible for tumor cell lysis by naive spleen cells and could be completely abolished by anti-TNF antiserum. It is suggested that the strong induction of TNF cytotoxicity may be important in the establishment of tumor immunity.
KW - CD4 cells
KW - Tumor immunity
UR - http://www.scopus.com/inward/record.url?scp=0029848903&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029848903&partnerID=8YFLogxK
M3 - Article
C2 - 8814262
AN - SCOPUS:0029848903
VL - 26
SP - 2160
EP - 2164
JO - European Journal of Immunology
JF - European Journal of Immunology
SN - 0014-2980
IS - 9
ER -