Abstract
The co-expression of B7.1 (CD80) and intercellular adhesion molecule (ICAM)-1 (CD54) on tumor cells can induce tumor immunity and immunological memory. We show here that the non-immunogenic tumor lines Lewis lung carcinoma and B16F10 melanoma, co-transfected with B7.1 and ICAM-1, induced cytotoxic levels of membrane tumor necrosis factor (TNF) on naive syngeneic T cells within 24 h. Membrane TNF expression, primarily on CD4 cells, was responsible for tumor cell lysis by naive spleen cells and could be completely abolished by anti-TNF antiserum. It is suggested that the strong induction of TNF cytotoxicity may be important in the establishment of tumor immunity.
Original language | English (US) |
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Pages (from-to) | 2160-2164 |
Number of pages | 5 |
Journal | European Journal of Immunology |
Volume | 26 |
Issue number | 9 |
DOIs | |
State | Published - 1996 |
Keywords
- CD4 cells
- Tumor immunity
ASJC Scopus subject areas
- Immunology