Rapid improvements in pain and quality of life are sustained after surgery for spinal metastases in a large prospective cohort

David Choi, Zoe Fox, Todd Albert, Mark Arts, Laurent Balabaud, Cody Bunger, Jacob Maciej Buchowski, Maarten Hubert Coppes, Bart Depreitere, Michael George Fehlings, James Harrop, Norio Kawahara, Juan Anthonio Martin-Benlloch, Eric Maurice Massicotte, Christian Mazel, Fetullah Cumhur Oner, Wilco Peul, Nasir Quraishi, Yasuaki Tokuhashi, Katsuro TomitaJorit Jan Verlaan, Miao Wang, Michael Wang, Hugh Alan Crockard

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Introduction Metastatic spinal cancer is a common condition that may lead to spinal instability, pain and paralysis. In the 1980s, surgery was discouraged because results showed worse neurological outcomes and pain compared with radiotherapy alone. However, with the advent of modern imaging and spinal stabilisation techniques, the role of surgery has regained centre stage, though few studies have assessed quality of life and functional outcomes after surgery. Objective We investigated whether surgery provides sustained improvement in quality of life and pain relief for patients with symptomatic spinal metastases by analysing the largest reported surgical series of patients with epidural spinal metastases. Methods A prospective cohort study of 922 consecutive patients with spinal metastases who underwent surgery, from the Global Spine Tumour Study Group database. Pre- and post-operative EQ-5D quality of life, visual analogue pain score, Karnofsky physical functioning score, complication rates and survival were recorded. Results Quality of life (EQ-5D), VAS pain score and Karnofsky physical functioning score improved rapidly after surgery and these improvements were sustained in those patients who survived up to 2 years after surgery. In specialised spine centres, the technical intra-operative complication rate of surgery was low, however almost a quarter of patients experienced post-operative systemic adverse events. Conclusion Surgical treatment for spinal metastases produces rapid pain relief, maintains ambulation and improves good quality of life. However, as a group, patients with cancer are vulnerable to post-operative systemic complications, hence the importance of appropriate patient selection.

Original languageEnglish (US)
Pages (from-to)337-344
Number of pages8
JournalBritish Journal of Neurosurgery
Volume30
Issue number3
DOIs
StatePublished - May 3 2016
Externally publishedYes

Keywords

  • Metastasis
  • outcome
  • quality of life
  • spine
  • surgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Rapid improvements in pain and quality of life are sustained after surgery for spinal metastases in a large prospective cohort'. Together they form a unique fingerprint.

Cite this