Rapid eye movement sleep alterations in myasthenia gravis

Oscar Papazian

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


The nocturnal sleep patterns of 10 patients with myasthenia gravis and five controls were recorded in the conventional manner for 7 hours on two consecutive nights. One patient was retested 4 weeks after institution of prednisone therapy. All the myasthenics had a significant disturbance in rapid eye movement (REM) sleep cycles. In the patient who was retested after clinically successful prednisone therapy, the REM sleep pattern had become normal. Since acetylcholine is the putative brain stem transmitter substance involved in the maintenance of REM sleep, the findings suggest a disturbed central mechanism of acetylcholine in myasthenia gravis.

Original languageEnglish (US)
Pages (from-to)311-316
Number of pages6
Issue number4
StatePublished - Apr 1976

ASJC Scopus subject areas

  • Clinical Neurology


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