Rapid analysis of total plasma homocysteine by tandem mass spectrometry

Karin Tuschl, Olaf A. Bodamer, Wolfgang Erwa, Adolf Mühl

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Elevated plasma homocysteine levels may be an independent risk factor for premature vascular disease. Early detection and population screening are warranted to recognise hyperhomocysteinemia and initiate homocysteine lowering therapy. Current methods for homocysteine analysis are time consuming, labor intensive and/or expensive. We developed a sensitive and fast method for homocysteine analysis based on tandem mass spectrometry that avoids the need for derivatization and preanalytical chromatography.

Original languageEnglish (US)
Pages (from-to)139-141
Number of pages3
JournalClinica Chimica Acta
Issue number1-2
StatePublished - Jan 2005


  • Analysis
  • Chromatography
  • Homocysteine
  • Mass spectrometry

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry


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