Abstract
Elevated plasma homocysteine levels may be an independent risk factor for premature vascular disease. Early detection and population screening are warranted to recognise hyperhomocysteinemia and initiate homocysteine lowering therapy. Current methods for homocysteine analysis are time consuming, labor intensive and/or expensive. We developed a sensitive and fast method for homocysteine analysis based on tandem mass spectrometry that avoids the need for derivatization and preanalytical chromatography.
| Original language | English |
|---|---|
| Pages (from-to) | 139-141 |
| Number of pages | 3 |
| Journal | Clinica Chimica Acta |
| Volume | 351 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Jan 1 2005 |
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Keywords
- Analysis
- Chromatography
- Homocysteine
- Mass spectrometry
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
Cite this
Rapid analysis of total plasma homocysteine by tandem mass spectrometry. / Tuschl, Karin; Bodamer, Olaf A.; Erwa, Wolfgang; Mühl, Adolf.
In: Clinica Chimica Acta, Vol. 351, No. 1-2, 01.01.2005, p. 139-141.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Rapid analysis of total plasma homocysteine by tandem mass spectrometry
AU - Tuschl, Karin
AU - Bodamer, Olaf A.
AU - Erwa, Wolfgang
AU - Mühl, Adolf
PY - 2005/1/1
Y1 - 2005/1/1
N2 - Elevated plasma homocysteine levels may be an independent risk factor for premature vascular disease. Early detection and population screening are warranted to recognise hyperhomocysteinemia and initiate homocysteine lowering therapy. Current methods for homocysteine analysis are time consuming, labor intensive and/or expensive. We developed a sensitive and fast method for homocysteine analysis based on tandem mass spectrometry that avoids the need for derivatization and preanalytical chromatography.
AB - Elevated plasma homocysteine levels may be an independent risk factor for premature vascular disease. Early detection and population screening are warranted to recognise hyperhomocysteinemia and initiate homocysteine lowering therapy. Current methods for homocysteine analysis are time consuming, labor intensive and/or expensive. We developed a sensitive and fast method for homocysteine analysis based on tandem mass spectrometry that avoids the need for derivatization and preanalytical chromatography.
KW - Analysis
KW - Chromatography
KW - Homocysteine
KW - Mass spectrometry
UR - http://www.scopus.com/inward/record.url?scp=9444292383&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=9444292383&partnerID=8YFLogxK
U2 - 10.1016/j.cccn.2004.08.016
DO - 10.1016/j.cccn.2004.08.016
M3 - Article
C2 - 15563882
AN - SCOPUS:9444292383
VL - 351
SP - 139
EP - 141
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
SN - 0009-8981
IS - 1-2
ER -