Rapid analysis of total plasma homocysteine by tandem mass spectrometry

Karin Tuschl; Olaf A. Bodamer; Wolfgang Erwa; Adolf Mühl

doi:10.1016/j.cccn.2004.08.016

Rapid analysis of total plasma homocysteine by tandem mass spectrometry

Karin Tuschl, Olaf A. Bodamer, Wolfgang Erwa, Adolf Mühl

Human Genetics

Research output: Contribution to journal › Article

28 Scopus citations

Abstract

Elevated plasma homocysteine levels may be an independent risk factor for premature vascular disease. Early detection and population screening are warranted to recognise hyperhomocysteinemia and initiate homocysteine lowering therapy. Current methods for homocysteine analysis are time consuming, labor intensive and/or expensive. We developed a sensitive and fast method for homocysteine analysis based on tandem mass spectrometry that avoids the need for derivatization and preanalytical chromatography.

Original language	English (US)
Pages (from-to)	139-141
Number of pages	3
Journal	Clinica Chimica Acta
Volume	351
Issue number	1-2
DOIs	https://doi.org/10.1016/j.cccn.2004.08.016
State	Published - Jan 1 2005

Fingerprint

Keywords

Analysis
Chromatography
Homocysteine
Mass spectrometry

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry

Cite this

Tuschl, K., Bodamer, O. A., Erwa, W., & Mühl, A. (2005). Rapid analysis of total plasma homocysteine by tandem mass spectrometry. Clinica Chimica Acta, 351(1-2), 139-141. https://doi.org/10.1016/j.cccn.2004.08.016

@article{9cfbfc6474624f28865689ddca9d5b4b,

title = "Rapid analysis of total plasma homocysteine by tandem mass spectrometry",

abstract = "Elevated plasma homocysteine levels may be an independent risk factor for premature vascular disease. Early detection and population screening are warranted to recognise hyperhomocysteinemia and initiate homocysteine lowering therapy. Current methods for homocysteine analysis are time consuming, labor intensive and/or expensive. We developed a sensitive and fast method for homocysteine analysis based on tandem mass spectrometry that avoids the need for derivatization and preanalytical chromatography.",

keywords = "Analysis, Chromatography, Homocysteine, Mass spectrometry",

author = "Karin Tuschl and Bodamer, {Olaf A.} and Wolfgang Erwa and Adolf M{\"u}hl",

year = "2005",

month = jan

day = "1",

doi = "10.1016/j.cccn.2004.08.016",

language = "English (US)",

volume = "351",

pages = "139--141",

journal = "Clinica Chimica Acta",

issn = "0009-8981",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Rapid analysis of total plasma homocysteine by tandem mass spectrometry

AU - Tuschl, Karin

AU - Bodamer, Olaf A.

AU - Erwa, Wolfgang

AU - Mühl, Adolf

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Elevated plasma homocysteine levels may be an independent risk factor for premature vascular disease. Early detection and population screening are warranted to recognise hyperhomocysteinemia and initiate homocysteine lowering therapy. Current methods for homocysteine analysis are time consuming, labor intensive and/or expensive. We developed a sensitive and fast method for homocysteine analysis based on tandem mass spectrometry that avoids the need for derivatization and preanalytical chromatography.

AB - Elevated plasma homocysteine levels may be an independent risk factor for premature vascular disease. Early detection and population screening are warranted to recognise hyperhomocysteinemia and initiate homocysteine lowering therapy. Current methods for homocysteine analysis are time consuming, labor intensive and/or expensive. We developed a sensitive and fast method for homocysteine analysis based on tandem mass spectrometry that avoids the need for derivatization and preanalytical chromatography.

KW - Analysis

KW - Chromatography

KW - Homocysteine

KW - Mass spectrometry

UR - http://www.scopus.com/inward/record.url?scp=9444292383&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=9444292383&partnerID=8YFLogxK

U2 - 10.1016/j.cccn.2004.08.016

DO - 10.1016/j.cccn.2004.08.016

M3 - Article

C2 - 15563882

AN - SCOPUS:9444292383

VL - 351

SP - 139

EP - 141

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

SN - 0009-8981

IS - 1-2

ER -

Access to Document

10.1016/j.cccn.2004.08.016