Rapid analysis of total plasma homocysteine by tandem mass spectrometry

Karin Tuschl, Olaf A. Bodamer, Wolfgang Erwa, Adolf Mühl

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Elevated plasma homocysteine levels may be an independent risk factor for premature vascular disease. Early detection and population screening are warranted to recognise hyperhomocysteinemia and initiate homocysteine lowering therapy. Current methods for homocysteine analysis are time consuming, labor intensive and/or expensive. We developed a sensitive and fast method for homocysteine analysis based on tandem mass spectrometry that avoids the need for derivatization and preanalytical chromatography.

Original languageEnglish
Pages (from-to)139-141
Number of pages3
JournalClinica Chimica Acta
Volume351
Issue number1-2
DOIs
StatePublished - Jan 1 2005

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Homocysteine
Tandem Mass Spectrometry
Mass spectrometry
Plasmas
Hyperhomocysteinemia
Chromatography
Vascular Diseases
Screening
Personnel
Population
Therapeutics

Keywords

  • Analysis
  • Chromatography
  • Homocysteine
  • Mass spectrometry

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

Cite this

Rapid analysis of total plasma homocysteine by tandem mass spectrometry. / Tuschl, Karin; Bodamer, Olaf A.; Erwa, Wolfgang; Mühl, Adolf.

In: Clinica Chimica Acta, Vol. 351, No. 1-2, 01.01.2005, p. 139-141.

Research output: Contribution to journalArticle

Tuschl, Karin ; Bodamer, Olaf A. ; Erwa, Wolfgang ; Mühl, Adolf. / Rapid analysis of total plasma homocysteine by tandem mass spectrometry. In: Clinica Chimica Acta. 2005 ; Vol. 351, No. 1-2. pp. 139-141.
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