Randomized Trial of a Tailored Cognitive-Behavioral Therapy Mobile Application for Anxiety in Patients with Incurable Cancer

Joseph A. Greer, Jamie Jacobs, Nicole Pensak, James J. MacDonald, Charn Xin Fuh, Giselle K. Perez, Alina Ward, Colleen Tallen, Alona Muzikansky, Lara Traeger, Frank J. Penedo, Areej El-Jawahri, Steven Safren, William F. Pirl, Jennifer S. Temel

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: The aim of this study was to test the efficacy of a tailored cognitive-behavioral therapy (CBT) mobile application (app) to treat anxiety in patients with incurable cancer. Materials and Methods: Patients with incurable cancers (n = 145) who reported elevated anxiety symptoms at two cancer centers were randomized to receive either the CBT mobile app for anxiety or a mobile health education program (control) delivered via tablet computers, which patients self-administered over 12 weeks. To assess anxiety, depression symptoms, and quality of life (QOL), we used the Hamilton Anxiety Rating Scale (HAM-A, primary outcome), Clinical Global Impression Scale, Hospital Anxiety and Depression Scale (HADS), Patient Health Questionnaire-9, and Functional Assessment of Cancer Therapy-General at baseline and 12 weeks. Analysis of covariance models were calculated to assess intervention effects on patient outcomes. Results: Patients (73.8% female; 91.0% white; mean age = 56.45 years, SD = 11.30) in both study groups reported improvements in anxiety, depression symptoms, and QOL from baseline to postassessment, with no significant differences in any outcome measure between groups. Secondary analyses showed that, among the subgroup of patients with severe baseline anxiety, those randomized to the CBT app had greater improvements on the HAM-A (Mean Difference = 7.44, standard error [SE] = 3.35, p =.037) and HADS-Anxiety Subscale (Mean Difference = 4.44, SE = 1.60, p =.010) compared with the control group. Conclusion: Both the tailored CBT app for anxiety and the health education program were associated with improvements in anxiety, mood, and QOL, but these outcomes did not differ between study groups. The CBT app was more beneficial than health education for patients with severe baseline anxiety. Implications for Practice: A cognitive-behavioral therapy mobile application tailored to treat anxiety in patients with advanced cancer helps improve access to evidence-based supportive care in a convenient, private, and timely manner.

Original languageEnglish (US)
JournalOncologist
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Mobile Applications
Cognitive Therapy
Anxiety
Neoplasms
Health Education
Depression
Quality of Life
Handheld Computers
Telemedicine
Patient Education

Keywords

  • Advanced cancer
  • Anxiety
  • Cognitive-behavioral therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Greer, J. A., Jacobs, J., Pensak, N., MacDonald, J. J., Fuh, C. X., Perez, G. K., ... Temel, J. S. (Accepted/In press). Randomized Trial of a Tailored Cognitive-Behavioral Therapy Mobile Application for Anxiety in Patients with Incurable Cancer. Oncologist. https://doi.org/10.1634/theoncologist.2018-0536

Randomized Trial of a Tailored Cognitive-Behavioral Therapy Mobile Application for Anxiety in Patients with Incurable Cancer. / Greer, Joseph A.; Jacobs, Jamie; Pensak, Nicole; MacDonald, James J.; Fuh, Charn Xin; Perez, Giselle K.; Ward, Alina; Tallen, Colleen; Muzikansky, Alona; Traeger, Lara; Penedo, Frank J.; El-Jawahri, Areej; Safren, Steven; Pirl, William F.; Temel, Jennifer S.

In: Oncologist, 01.01.2019.

Research output: Contribution to journalArticle

Greer, JA, Jacobs, J, Pensak, N, MacDonald, JJ, Fuh, CX, Perez, GK, Ward, A, Tallen, C, Muzikansky, A, Traeger, L, Penedo, FJ, El-Jawahri, A, Safren, S, Pirl, WF & Temel, JS 2019, 'Randomized Trial of a Tailored Cognitive-Behavioral Therapy Mobile Application for Anxiety in Patients with Incurable Cancer', Oncologist. https://doi.org/10.1634/theoncologist.2018-0536
Greer, Joseph A. ; Jacobs, Jamie ; Pensak, Nicole ; MacDonald, James J. ; Fuh, Charn Xin ; Perez, Giselle K. ; Ward, Alina ; Tallen, Colleen ; Muzikansky, Alona ; Traeger, Lara ; Penedo, Frank J. ; El-Jawahri, Areej ; Safren, Steven ; Pirl, William F. ; Temel, Jennifer S. / Randomized Trial of a Tailored Cognitive-Behavioral Therapy Mobile Application for Anxiety in Patients with Incurable Cancer. In: Oncologist. 2019.
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abstract = "Background: The aim of this study was to test the efficacy of a tailored cognitive-behavioral therapy (CBT) mobile application (app) to treat anxiety in patients with incurable cancer. Materials and Methods: Patients with incurable cancers (n = 145) who reported elevated anxiety symptoms at two cancer centers were randomized to receive either the CBT mobile app for anxiety or a mobile health education program (control) delivered via tablet computers, which patients self-administered over 12 weeks. To assess anxiety, depression symptoms, and quality of life (QOL), we used the Hamilton Anxiety Rating Scale (HAM-A, primary outcome), Clinical Global Impression Scale, Hospital Anxiety and Depression Scale (HADS), Patient Health Questionnaire-9, and Functional Assessment of Cancer Therapy-General at baseline and 12 weeks. Analysis of covariance models were calculated to assess intervention effects on patient outcomes. Results: Patients (73.8{\%} female; 91.0{\%} white; mean age = 56.45 years, SD = 11.30) in both study groups reported improvements in anxiety, depression symptoms, and QOL from baseline to postassessment, with no significant differences in any outcome measure between groups. Secondary analyses showed that, among the subgroup of patients with severe baseline anxiety, those randomized to the CBT app had greater improvements on the HAM-A (Mean Difference = 7.44, standard error [SE] = 3.35, p =.037) and HADS-Anxiety Subscale (Mean Difference = 4.44, SE = 1.60, p =.010) compared with the control group. Conclusion: Both the tailored CBT app for anxiety and the health education program were associated with improvements in anxiety, mood, and QOL, but these outcomes did not differ between study groups. The CBT app was more beneficial than health education for patients with severe baseline anxiety. Implications for Practice: A cognitive-behavioral therapy mobile application tailored to treat anxiety in patients with advanced cancer helps improve access to evidence-based supportive care in a convenient, private, and timely manner.",
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