Randomized prospective double-blind studies to evaluate the cognitive effects of inositol-stabilized arginine silicate in healthy physically active adults

Douglas Kalman, Philip D. Harvey, Sara Perez Ojalvo, James Komorowski

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Inositol-stabilized arginine silicate (ASI; Nitrosigine®) has been validated to increase levels of arginine, silicon and nitric oxide production. To evaluate potential enhancement of mental focus and clarity, ASI (1500 mg/day) was tested in two double-blind placebo-controlled crossover (DBPC-X) studies using the Trail Making Test (TMT, Parts A and B). In the two studies, healthy males took ASI for 14 and 3 days, respectively. In the first study, after 14 days of dosing, TMT B time decreased significantly from baseline (28% improvement, p = 0.045). In the second study evaluating shorter-term effects, TMT B time decreased significantly compared to placebo (33% improvement, p = 0.024) in a 10-min period. After 3 days of dosing, TMT B time significantly decreased from baseline scores (35% improvement, p < 0.001). These findings show that ASI significantly improved the ability to perform complex cognitive tests requiring mental flexibility, processing speed and executive functioning.

Original languageEnglish (US)
Article number736
JournalNutrients
Volume8
Issue number11
DOIs
StatePublished - Nov 18 2016

Keywords

  • Cognitive function
  • L-arginine
  • Mental flexibility
  • Nitric oxide
  • Silicate

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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