Randomized phase II clinical trial of adriamycin, methotrexate, and actinomycin-D in advanced measurable pancreatic carcinoma. A gastrointestinal tumor study group report

P. S. Schein, P. T. Lavin, C. G. Moertel, S. Frytak, R. G. Hahn, M. J. O'Connell, R. J. Reitemeier, J. Rubin, A. J. Schutt, L. H. Weiland, M. Kalser, Jamie S Barkin, H. Lessner, R. Mann-Kaplan, D. Redlhammer, M. Silverman, M. Troner, H. O. Douglass, S. Milliron, J. LokichJ. Brooks, J. Chaffe, A. Like, N. Zamcheck, K. Ramming, J. Bateman, H. Spiro, E. Livstone, A. Knowlton

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Abstract

Sixty-six patients with advanced pancreatic carcinoma were randomized to receive single agent chemotherapy with either adriamycin, methotrexate, or actinomycin-D using conventional dose, route and schedule of administration. All patients had measurable lesions which were used for objective assessment of response. For adriamycin, 2 of 25 patients (8%) evidenced a partial response (2 of 15 (13%) previously untreated patients). One of 25 patients treated with methotrexate and one of 28 who received actinomycin-D responded. The duration of responses ranged from 43-64 days for those patients with no chemotherapy prior to study entry. The median survival of patients who received adriamycin as initial treatment was 12 weeks compared to 8 weeks for methotrexate and 6 weeks for actinomycin-D therapy.

Original languageEnglish
Pages (from-to)19-22
Number of pages4
JournalCancer
Volume42
Issue number1
StatePublished - Dec 1 1978

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Phase II Clinical Trials
Dactinomycin
Methotrexate
Doxorubicin
Randomized Controlled Trials
Neoplasms
Drug Therapy
Pancreatic Carcinoma
Appointments and Schedules
Survival
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Schein, P. S., Lavin, P. T., Moertel, C. G., Frytak, S., Hahn, R. G., O'Connell, M. J., ... Knowlton, A. (1978). Randomized phase II clinical trial of adriamycin, methotrexate, and actinomycin-D in advanced measurable pancreatic carcinoma. A gastrointestinal tumor study group report. Cancer, 42(1), 19-22.

Randomized phase II clinical trial of adriamycin, methotrexate, and actinomycin-D in advanced measurable pancreatic carcinoma. A gastrointestinal tumor study group report. / Schein, P. S.; Lavin, P. T.; Moertel, C. G.; Frytak, S.; Hahn, R. G.; O'Connell, M. J.; Reitemeier, R. J.; Rubin, J.; Schutt, A. J.; Weiland, L. H.; Kalser, M.; Barkin, Jamie S; Lessner, H.; Mann-Kaplan, R.; Redlhammer, D.; Silverman, M.; Troner, M.; Douglass, H. O.; Milliron, S.; Lokich, J.; Brooks, J.; Chaffe, J.; Like, A.; Zamcheck, N.; Ramming, K.; Bateman, J.; Spiro, H.; Livstone, E.; Knowlton, A.

In: Cancer, Vol. 42, No. 1, 01.12.1978, p. 19-22.

Research output: Contribution to journalArticle

Schein, PS, Lavin, PT, Moertel, CG, Frytak, S, Hahn, RG, O'Connell, MJ, Reitemeier, RJ, Rubin, J, Schutt, AJ, Weiland, LH, Kalser, M, Barkin, JS, Lessner, H, Mann-Kaplan, R, Redlhammer, D, Silverman, M, Troner, M, Douglass, HO, Milliron, S, Lokich, J, Brooks, J, Chaffe, J, Like, A, Zamcheck, N, Ramming, K, Bateman, J, Spiro, H, Livstone, E & Knowlton, A 1978, 'Randomized phase II clinical trial of adriamycin, methotrexate, and actinomycin-D in advanced measurable pancreatic carcinoma. A gastrointestinal tumor study group report', Cancer, vol. 42, no. 1, pp. 19-22.
Schein, P. S. ; Lavin, P. T. ; Moertel, C. G. ; Frytak, S. ; Hahn, R. G. ; O'Connell, M. J. ; Reitemeier, R. J. ; Rubin, J. ; Schutt, A. J. ; Weiland, L. H. ; Kalser, M. ; Barkin, Jamie S ; Lessner, H. ; Mann-Kaplan, R. ; Redlhammer, D. ; Silverman, M. ; Troner, M. ; Douglass, H. O. ; Milliron, S. ; Lokich, J. ; Brooks, J. ; Chaffe, J. ; Like, A. ; Zamcheck, N. ; Ramming, K. ; Bateman, J. ; Spiro, H. ; Livstone, E. ; Knowlton, A. / Randomized phase II clinical trial of adriamycin, methotrexate, and actinomycin-D in advanced measurable pancreatic carcinoma. A gastrointestinal tumor study group report. In: Cancer. 1978 ; Vol. 42, No. 1. pp. 19-22.
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abstract = "Sixty-six patients with advanced pancreatic carcinoma were randomized to receive single agent chemotherapy with either adriamycin, methotrexate, or actinomycin-D using conventional dose, route and schedule of administration. All patients had measurable lesions which were used for objective assessment of response. For adriamycin, 2 of 25 patients (8{\%}) evidenced a partial response (2 of 15 (13{\%}) previously untreated patients). One of 25 patients treated with methotrexate and one of 28 who received actinomycin-D responded. The duration of responses ranged from 43-64 days for those patients with no chemotherapy prior to study entry. The median survival of patients who received adriamycin as initial treatment was 12 weeks compared to 8 weeks for methotrexate and 6 weeks for actinomycin-D therapy.",
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AU - Lavin, P. T.

AU - Moertel, C. G.

AU - Frytak, S.

AU - Hahn, R. G.

AU - O'Connell, M. J.

AU - Reitemeier, R. J.

AU - Rubin, J.

AU - Schutt, A. J.

AU - Weiland, L. H.

AU - Kalser, M.

AU - Barkin, Jamie S

AU - Lessner, H.

AU - Mann-Kaplan, R.

AU - Redlhammer, D.

AU - Silverman, M.

AU - Troner, M.

AU - Douglass, H. O.

AU - Milliron, S.

AU - Lokich, J.

AU - Brooks, J.

AU - Chaffe, J.

AU - Like, A.

AU - Zamcheck, N.

AU - Ramming, K.

AU - Bateman, J.

AU - Spiro, H.

AU - Livstone, E.

AU - Knowlton, A.

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