Randomized double-masked trial of sodium oxyferriscorbone for the treatment of gastric ulcers

J. C. Meeroff, M. Rubinstein, A. Luis, M. Waciarz, O. Eguia, M. Meeroff

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A double-blind 4-week trial of sodium oxyferriscorbone versus placebo (distilled water) was conducted in 46 outpatients with endoscopically confirmed gastric ulcer. Ulcer healing occurred in 15 of 20 patients receiving sodium oxyferriscorbone (75%) and in 7 of 20 patients receiving placebo (35%). Patients receiving sodium oxyferriscorbone experienced less pain and required less antacid than those receiving placebo (P<0.05). Side effects were reported in 12 patients, 7 while receiving sodium oxyferriscorbone and 5 while receiving placebo. Six patients did not complete the study due to ulcer complications. Routine laboratory tests revealed no persistent abnormalities that could be related to the treatment. Five placebo-treated patients that were therapeutic failures were switched to sodium oxyferriscorbone and healing was observed within 3 weeks. It is concluded that sodium oxyferriscorbone is effective in enhancing healing of gastric ulcers.

Original languageEnglish
Pages (from-to)680-683
Number of pages4
JournalDigestive Diseases and Sciences
Volume24
Issue number9
DOIs
StatePublished - Sep 1 1979

Fingerprint

Stomach Ulcer
Placebos
Ulcer
Therapeutics
Antacids
oxyferriscorbone
Outpatients
Pain
Water

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Meeroff, J. C., Rubinstein, M., Luis, A., Waciarz, M., Eguia, O., & Meeroff, M. (1979). Randomized double-masked trial of sodium oxyferriscorbone for the treatment of gastric ulcers. Digestive Diseases and Sciences, 24(9), 680-683. https://doi.org/10.1007/BF01314464

Randomized double-masked trial of sodium oxyferriscorbone for the treatment of gastric ulcers. / Meeroff, J. C.; Rubinstein, M.; Luis, A.; Waciarz, M.; Eguia, O.; Meeroff, M.

In: Digestive Diseases and Sciences, Vol. 24, No. 9, 01.09.1979, p. 680-683.

Research output: Contribution to journalArticle

Meeroff, JC, Rubinstein, M, Luis, A, Waciarz, M, Eguia, O & Meeroff, M 1979, 'Randomized double-masked trial of sodium oxyferriscorbone for the treatment of gastric ulcers', Digestive Diseases and Sciences, vol. 24, no. 9, pp. 680-683. https://doi.org/10.1007/BF01314464
Meeroff, J. C. ; Rubinstein, M. ; Luis, A. ; Waciarz, M. ; Eguia, O. ; Meeroff, M. / Randomized double-masked trial of sodium oxyferriscorbone for the treatment of gastric ulcers. In: Digestive Diseases and Sciences. 1979 ; Vol. 24, No. 9. pp. 680-683.
@article{789ec584dabe4b2897ff65da19f371ba,
title = "Randomized double-masked trial of sodium oxyferriscorbone for the treatment of gastric ulcers",
abstract = "A double-blind 4-week trial of sodium oxyferriscorbone versus placebo (distilled water) was conducted in 46 outpatients with endoscopically confirmed gastric ulcer. Ulcer healing occurred in 15 of 20 patients receiving sodium oxyferriscorbone (75{\%}) and in 7 of 20 patients receiving placebo (35{\%}). Patients receiving sodium oxyferriscorbone experienced less pain and required less antacid than those receiving placebo (P<0.05). Side effects were reported in 12 patients, 7 while receiving sodium oxyferriscorbone and 5 while receiving placebo. Six patients did not complete the study due to ulcer complications. Routine laboratory tests revealed no persistent abnormalities that could be related to the treatment. Five placebo-treated patients that were therapeutic failures were switched to sodium oxyferriscorbone and healing was observed within 3 weeks. It is concluded that sodium oxyferriscorbone is effective in enhancing healing of gastric ulcers.",
author = "Meeroff, {J. C.} and M. Rubinstein and A. Luis and M. Waciarz and O. Eguia and M. Meeroff",
year = "1979",
month = "9",
day = "1",
doi = "10.1007/BF01314464",
language = "English",
volume = "24",
pages = "680--683",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Plenum Publishers",
number = "9",

}

TY - JOUR

T1 - Randomized double-masked trial of sodium oxyferriscorbone for the treatment of gastric ulcers

AU - Meeroff, J. C.

AU - Rubinstein, M.

AU - Luis, A.

AU - Waciarz, M.

AU - Eguia, O.

AU - Meeroff, M.

PY - 1979/9/1

Y1 - 1979/9/1

N2 - A double-blind 4-week trial of sodium oxyferriscorbone versus placebo (distilled water) was conducted in 46 outpatients with endoscopically confirmed gastric ulcer. Ulcer healing occurred in 15 of 20 patients receiving sodium oxyferriscorbone (75%) and in 7 of 20 patients receiving placebo (35%). Patients receiving sodium oxyferriscorbone experienced less pain and required less antacid than those receiving placebo (P<0.05). Side effects were reported in 12 patients, 7 while receiving sodium oxyferriscorbone and 5 while receiving placebo. Six patients did not complete the study due to ulcer complications. Routine laboratory tests revealed no persistent abnormalities that could be related to the treatment. Five placebo-treated patients that were therapeutic failures were switched to sodium oxyferriscorbone and healing was observed within 3 weeks. It is concluded that sodium oxyferriscorbone is effective in enhancing healing of gastric ulcers.

AB - A double-blind 4-week trial of sodium oxyferriscorbone versus placebo (distilled water) was conducted in 46 outpatients with endoscopically confirmed gastric ulcer. Ulcer healing occurred in 15 of 20 patients receiving sodium oxyferriscorbone (75%) and in 7 of 20 patients receiving placebo (35%). Patients receiving sodium oxyferriscorbone experienced less pain and required less antacid than those receiving placebo (P<0.05). Side effects were reported in 12 patients, 7 while receiving sodium oxyferriscorbone and 5 while receiving placebo. Six patients did not complete the study due to ulcer complications. Routine laboratory tests revealed no persistent abnormalities that could be related to the treatment. Five placebo-treated patients that were therapeutic failures were switched to sodium oxyferriscorbone and healing was observed within 3 weeks. It is concluded that sodium oxyferriscorbone is effective in enhancing healing of gastric ulcers.

UR - http://www.scopus.com/inward/record.url?scp=0018673772&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018673772&partnerID=8YFLogxK

U2 - 10.1007/BF01314464

DO - 10.1007/BF01314464

M3 - Article

C2 - 385261

AN - SCOPUS:0018673772

VL - 24

SP - 680

EP - 683

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 9

ER -