Randomized clinical trial of telephone-administered cognitive-behavioral therapy to reduce post-traumatic stress disorder and distress symptoms after hematopoietic stem-cell transplantation

Katherine N. DuHamel, Catherine E. Mosher, Gary Winkel, Larissa E. Labay, Christine Rini, Yeraz Markarian Meschian, Jane Austin, Paul B. Greene, Catalina R. Lawsin, Anna Rusiewicz, Celia L. Grosskreutz, Luis Isola, Craig Moskowitz, Esperanza B. Papadopoulos, Scott Rowley, Eileen Scigliano, Jack E. Burkhalter, Karen E. Hurley, Andreas R. Bollinger, William H. Redd

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Purpose: A significant number of survivors of hematopoietic stem-cell transplantation (HSCT) report enduring adverse effects of treatment, including illness-related post-traumatic stress disorder (PTSD) symptoms and general distress. We report results of a randomized clinical trial that tested the effects of a 10-session, telephone-administered cognitive-behavioral therapy (CBT) intervention on PTSD, depression, and distress symptoms. Methods: Survivors who had undergone HSCT 1 to 3 years earlier (N = 408) were assessed for study eligibility. Those who met study eligibility criteria (n = 89) completed a baseline assessment that included a clinical interview and self-report measures of PTSD symptoms (the primary outcome) and depression and general distress (the secondary outcomes). Next, they were randomly assigned to CBT or an assessment-only condition. Survivors in the CBT group completed 10 individual telephone-based CBT sessions (T-CBT) that included strategies to reduce PTSD symptoms, depression, and general distress. Follow-up assessments occurred at 6, 9, and 12 months after the baseline assessment. Results: Linear mixed-model analyses revealed that, compared with HSCT survivors in the assessment-only condition, survivors who completed T-CBT reported fewer illness-related PTSD symptoms, including less avoidance (P < .001) and fewer intrusive thoughts (P < .05) as well as less general distress and fewer depressive symptoms (P < .05) even after controlling for potential demographic and medical covariates. These results were consistent across the three follow-up assessments. Conclusion: A brief, telephone-administered CBT intervention developed for HSCT survivors is an efficacious treatment for reducing illness-related PTSD symptoms and general distress.

Original languageEnglish (US)
Pages (from-to)3754-3761
Number of pages8
JournalJournal of Clinical Oncology
Volume28
Issue number23
DOIs
StatePublished - Aug 10 2010
Externally publishedYes

Fingerprint

Hematopoietic Stem Cell Transplantation
Cognitive Therapy
Post-Traumatic Stress Disorders
Telephone
Survivors
Randomized Controlled Trials
Depression
Self Report
Linear Models
Demography
Interviews
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Randomized clinical trial of telephone-administered cognitive-behavioral therapy to reduce post-traumatic stress disorder and distress symptoms after hematopoietic stem-cell transplantation. / DuHamel, Katherine N.; Mosher, Catherine E.; Winkel, Gary; Labay, Larissa E.; Rini, Christine; Meschian, Yeraz Markarian; Austin, Jane; Greene, Paul B.; Lawsin, Catalina R.; Rusiewicz, Anna; Grosskreutz, Celia L.; Isola, Luis; Moskowitz, Craig; Papadopoulos, Esperanza B.; Rowley, Scott; Scigliano, Eileen; Burkhalter, Jack E.; Hurley, Karen E.; Bollinger, Andreas R.; Redd, William H.

In: Journal of Clinical Oncology, Vol. 28, No. 23, 10.08.2010, p. 3754-3761.

Research output: Contribution to journalArticle

DuHamel, KN, Mosher, CE, Winkel, G, Labay, LE, Rini, C, Meschian, YM, Austin, J, Greene, PB, Lawsin, CR, Rusiewicz, A, Grosskreutz, CL, Isola, L, Moskowitz, C, Papadopoulos, EB, Rowley, S, Scigliano, E, Burkhalter, JE, Hurley, KE, Bollinger, AR & Redd, WH 2010, 'Randomized clinical trial of telephone-administered cognitive-behavioral therapy to reduce post-traumatic stress disorder and distress symptoms after hematopoietic stem-cell transplantation', Journal of Clinical Oncology, vol. 28, no. 23, pp. 3754-3761. https://doi.org/10.1200/JCO.2009.26.8722
DuHamel, Katherine N. ; Mosher, Catherine E. ; Winkel, Gary ; Labay, Larissa E. ; Rini, Christine ; Meschian, Yeraz Markarian ; Austin, Jane ; Greene, Paul B. ; Lawsin, Catalina R. ; Rusiewicz, Anna ; Grosskreutz, Celia L. ; Isola, Luis ; Moskowitz, Craig ; Papadopoulos, Esperanza B. ; Rowley, Scott ; Scigliano, Eileen ; Burkhalter, Jack E. ; Hurley, Karen E. ; Bollinger, Andreas R. ; Redd, William H. / Randomized clinical trial of telephone-administered cognitive-behavioral therapy to reduce post-traumatic stress disorder and distress symptoms after hematopoietic stem-cell transplantation. In: Journal of Clinical Oncology. 2010 ; Vol. 28, No. 23. pp. 3754-3761.
@article{2ca0ee993930465492c285706673f871,
title = "Randomized clinical trial of telephone-administered cognitive-behavioral therapy to reduce post-traumatic stress disorder and distress symptoms after hematopoietic stem-cell transplantation",
abstract = "Purpose: A significant number of survivors of hematopoietic stem-cell transplantation (HSCT) report enduring adverse effects of treatment, including illness-related post-traumatic stress disorder (PTSD) symptoms and general distress. We report results of a randomized clinical trial that tested the effects of a 10-session, telephone-administered cognitive-behavioral therapy (CBT) intervention on PTSD, depression, and distress symptoms. Methods: Survivors who had undergone HSCT 1 to 3 years earlier (N = 408) were assessed for study eligibility. Those who met study eligibility criteria (n = 89) completed a baseline assessment that included a clinical interview and self-report measures of PTSD symptoms (the primary outcome) and depression and general distress (the secondary outcomes). Next, they were randomly assigned to CBT or an assessment-only condition. Survivors in the CBT group completed 10 individual telephone-based CBT sessions (T-CBT) that included strategies to reduce PTSD symptoms, depression, and general distress. Follow-up assessments occurred at 6, 9, and 12 months after the baseline assessment. Results: Linear mixed-model analyses revealed that, compared with HSCT survivors in the assessment-only condition, survivors who completed T-CBT reported fewer illness-related PTSD symptoms, including less avoidance (P < .001) and fewer intrusive thoughts (P < .05) as well as less general distress and fewer depressive symptoms (P < .05) even after controlling for potential demographic and medical covariates. These results were consistent across the three follow-up assessments. Conclusion: A brief, telephone-administered CBT intervention developed for HSCT survivors is an efficacious treatment for reducing illness-related PTSD symptoms and general distress.",
author = "DuHamel, {Katherine N.} and Mosher, {Catherine E.} and Gary Winkel and Labay, {Larissa E.} and Christine Rini and Meschian, {Yeraz Markarian} and Jane Austin and Greene, {Paul B.} and Lawsin, {Catalina R.} and Anna Rusiewicz and Grosskreutz, {Celia L.} and Luis Isola and Craig Moskowitz and Papadopoulos, {Esperanza B.} and Scott Rowley and Eileen Scigliano and Burkhalter, {Jack E.} and Hurley, {Karen E.} and Bollinger, {Andreas R.} and Redd, {William H.}",
year = "2010",
month = "8",
day = "10",
doi = "10.1200/JCO.2009.26.8722",
language = "English (US)",
volume = "28",
pages = "3754--3761",
journal = "Journal of Clinical Oncology",
issn = "0732-183X",
publisher = "American Society of Clinical Oncology",
number = "23",

}

TY - JOUR

T1 - Randomized clinical trial of telephone-administered cognitive-behavioral therapy to reduce post-traumatic stress disorder and distress symptoms after hematopoietic stem-cell transplantation

AU - DuHamel, Katherine N.

AU - Mosher, Catherine E.

AU - Winkel, Gary

AU - Labay, Larissa E.

AU - Rini, Christine

AU - Meschian, Yeraz Markarian

AU - Austin, Jane

AU - Greene, Paul B.

AU - Lawsin, Catalina R.

AU - Rusiewicz, Anna

AU - Grosskreutz, Celia L.

AU - Isola, Luis

AU - Moskowitz, Craig

AU - Papadopoulos, Esperanza B.

AU - Rowley, Scott

AU - Scigliano, Eileen

AU - Burkhalter, Jack E.

AU - Hurley, Karen E.

AU - Bollinger, Andreas R.

AU - Redd, William H.

PY - 2010/8/10

Y1 - 2010/8/10

N2 - Purpose: A significant number of survivors of hematopoietic stem-cell transplantation (HSCT) report enduring adverse effects of treatment, including illness-related post-traumatic stress disorder (PTSD) symptoms and general distress. We report results of a randomized clinical trial that tested the effects of a 10-session, telephone-administered cognitive-behavioral therapy (CBT) intervention on PTSD, depression, and distress symptoms. Methods: Survivors who had undergone HSCT 1 to 3 years earlier (N = 408) were assessed for study eligibility. Those who met study eligibility criteria (n = 89) completed a baseline assessment that included a clinical interview and self-report measures of PTSD symptoms (the primary outcome) and depression and general distress (the secondary outcomes). Next, they were randomly assigned to CBT or an assessment-only condition. Survivors in the CBT group completed 10 individual telephone-based CBT sessions (T-CBT) that included strategies to reduce PTSD symptoms, depression, and general distress. Follow-up assessments occurred at 6, 9, and 12 months after the baseline assessment. Results: Linear mixed-model analyses revealed that, compared with HSCT survivors in the assessment-only condition, survivors who completed T-CBT reported fewer illness-related PTSD symptoms, including less avoidance (P < .001) and fewer intrusive thoughts (P < .05) as well as less general distress and fewer depressive symptoms (P < .05) even after controlling for potential demographic and medical covariates. These results were consistent across the three follow-up assessments. Conclusion: A brief, telephone-administered CBT intervention developed for HSCT survivors is an efficacious treatment for reducing illness-related PTSD symptoms and general distress.

AB - Purpose: A significant number of survivors of hematopoietic stem-cell transplantation (HSCT) report enduring adverse effects of treatment, including illness-related post-traumatic stress disorder (PTSD) symptoms and general distress. We report results of a randomized clinical trial that tested the effects of a 10-session, telephone-administered cognitive-behavioral therapy (CBT) intervention on PTSD, depression, and distress symptoms. Methods: Survivors who had undergone HSCT 1 to 3 years earlier (N = 408) were assessed for study eligibility. Those who met study eligibility criteria (n = 89) completed a baseline assessment that included a clinical interview and self-report measures of PTSD symptoms (the primary outcome) and depression and general distress (the secondary outcomes). Next, they were randomly assigned to CBT or an assessment-only condition. Survivors in the CBT group completed 10 individual telephone-based CBT sessions (T-CBT) that included strategies to reduce PTSD symptoms, depression, and general distress. Follow-up assessments occurred at 6, 9, and 12 months after the baseline assessment. Results: Linear mixed-model analyses revealed that, compared with HSCT survivors in the assessment-only condition, survivors who completed T-CBT reported fewer illness-related PTSD symptoms, including less avoidance (P < .001) and fewer intrusive thoughts (P < .05) as well as less general distress and fewer depressive symptoms (P < .05) even after controlling for potential demographic and medical covariates. These results were consistent across the three follow-up assessments. Conclusion: A brief, telephone-administered CBT intervention developed for HSCT survivors is an efficacious treatment for reducing illness-related PTSD symptoms and general distress.

UR - http://www.scopus.com/inward/record.url?scp=77957285292&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957285292&partnerID=8YFLogxK

U2 - 10.1200/JCO.2009.26.8722

DO - 10.1200/JCO.2009.26.8722

M3 - Article

VL - 28

SP - 3754

EP - 3761

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

SN - 0732-183X

IS - 23

ER -