RAGE and its ligands: a lasting memory in diabetic complications?

Shi Fang Yan, Ravichandran Ramasamy, Loredana G. Bucciarelli, Thoralf Wendt, Larisse K. Lee, Barry Hudson, David M. Stern, Evanthia Lalla, Shi DU Yan, Ling Ling Rong, Yoshifumi Naka, Ann Marie Schmidt

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The complications of diabetes are myriad and represent a rising cause of morbidity and mortality, particularly in the Western world. The update of the Diabetes Control and Clinical Trials Group/Epidemiology of Diabetes Interventions and Complications Research Group (DCCT/EDIC) suggested that previous strict control of hyperglycaemia was associated with reduced carotid atherosclerosis compared to conventional treatment, even after levels of glycosylated haemoglobin between the two treatment groups became indistinguishable. These intriguing findings prompt the key question, why does the blood vessel 'remember'? This review focuses on the hypothesis that the ligand/RAGE axis contributes importantly to glycaemic 'memory'. Studies in rodent models of diabetes suggest that blockade or genetic modification of RAGE suppress diabetes-associated progression of atherosclerosis, exaggerated neointimal expansion consequent to acute arterial injury, and cardiac dysfunction. We propose that therapeutic RAGE blockade will intercept maladaptive diabetes-associated memory in the vessel wall and provide cardiovascular protection in diabetes.

Original languageEnglish
Pages (from-to)10-20
Number of pages11
JournalDiabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease.
Volume1
Issue number1
StatePublished - May 1 2004
Externally publishedYes

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Diabetes Complications
Ligands
Western World
Carotid Artery Diseases
Glycosylated Hemoglobin A
Hyperglycemia
Blood Vessels
Rodentia
Atherosclerosis
Epidemiology
Clinical Trials
Morbidity
Mortality
Wounds and Injuries
Research
Therapeutics

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

Cite this

RAGE and its ligands : a lasting memory in diabetic complications? / Yan, Shi Fang; Ramasamy, Ravichandran; Bucciarelli, Loredana G.; Wendt, Thoralf; Lee, Larisse K.; Hudson, Barry; Stern, David M.; Lalla, Evanthia; DU Yan, Shi; Rong, Ling Ling; Naka, Yoshifumi; Schmidt, Ann Marie.

In: Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease., Vol. 1, No. 1, 01.05.2004, p. 10-20.

Research output: Contribution to journalArticle

Yan, SF, Ramasamy, R, Bucciarelli, LG, Wendt, T, Lee, LK, Hudson, B, Stern, DM, Lalla, E, DU Yan, S, Rong, LL, Naka, Y & Schmidt, AM 2004, 'RAGE and its ligands: a lasting memory in diabetic complications?', Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease., vol. 1, no. 1, pp. 10-20.
Yan, Shi Fang ; Ramasamy, Ravichandran ; Bucciarelli, Loredana G. ; Wendt, Thoralf ; Lee, Larisse K. ; Hudson, Barry ; Stern, David M. ; Lalla, Evanthia ; DU Yan, Shi ; Rong, Ling Ling ; Naka, Yoshifumi ; Schmidt, Ann Marie. / RAGE and its ligands : a lasting memory in diabetic complications?. In: Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease. 2004 ; Vol. 1, No. 1. pp. 10-20.
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AU - Stern, David M.

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