Radionuclide cerebral perfusion scintigraphy in determination of brain death in children

Bernard H. Holzman, Richard G. Curless, George N. Sfakianakis, Cosimo Ajmone-Marsan, Jorge E. Montes

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

We evaluated a radionuclide scintigraphic technique for imaging relative cerebral perfusion in 18 children who had no evidence of cortical and brainstem function. Patients without scintigraphic evidence of cerebral perfusion all later met criteria for diagnosis of brain death. Patients who failed to satisfy brain-death criteria had persistent scintigraphic evidence of cerebral perfusion. Seven patients with normal scintigraphic studies were being treated with barbiturates and hypothermia at levels that attenuated or completely suppressed EEG activity. Four patients without scintigraphic evidence of cerebral perfusion had mean arterial pressures (MAP) higher than (54.8 ± 7.6 torr) intracranial pressures (ICP) at the time of scintigraphic study, suggesting that ICP in excess of MAP is not the sole explanation for absence of cerebral perfusion. Radionuclide cerebral perfusion scintigraphy (RCPS) is a rapid, portable, accurate test that appears to be useful in the diagnosis of brain death in the pediatric population.

Original languageEnglish (US)
Pages (from-to)1027-1031
Number of pages5
JournalNeurology
Volume33
Issue number8
DOIs
StatePublished - Aug 1983

ASJC Scopus subject areas

  • Clinical Neurology

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    Holzman, B. H., Curless, R. G., Sfakianakis, G. N., Ajmone-Marsan, C., & Montes, J. E. (1983). Radionuclide cerebral perfusion scintigraphy in determination of brain death in children. Neurology, 33(8), 1027-1031. https://doi.org/10.1212/wnl.33.8.1027