Radiofrequency ablation of rabbit kidney using liquid electrode: Acute and chronic observations

Vipul R. Patel, Raymond J. Leveillee, Michael F. Hoey, Alan J. Herron, Julia Zaias, John C. Hulbert

Research output: Contribution to journalArticle

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Abstract

Background and Purpose: The percentage of small renal tumors being diagnosed has increased at least fivefold in the last 20 years. The question of bow best to treat these lesions remains unanswered. We studied the effectiveness of 'wet' radiofrequency (RF) ablation of renal tissue. Materials and Methods: New Zealand white rabbits (N = 48) underwent a 1- or 2-minute ablation of renal parenchyma with a modified insulated spinal needle capable of infusing saline, measuring temperature and impedance, and delivering RF energy. Animals were followed and examined up to 54 days after surgery. Results: All animals survived for the planned period. Intravenous urograms showed no fistula or urinoma formation and confirmed continued function of the remaining parenchyma. The 1-minute treatments consistently ablated 20% to 25% (average 7 cm) of the tissue, whereas the 2-minute treatments ablated 34% to 36% (average 10 cm). Acutely, there was coagulative necrosis and infiltration of inflammatory cells. Chronically, there were well-demarcated lesions with complete effacement of the tubular epithelium and destruction of the glomeruli. Conclusion: Wet radiofrequency ablation with a liquid electrode can reproducibly create large lesions safely and quickly. The technique may soon become an alternative, minimally invasive therapy for small renal tumors.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalJournal of Endourology
Volume14
Issue number2
StatePublished - Apr 20 2000

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Electrodes
Rabbits
Kidney
Urinoma
Urography
Electric Impedance
Ambulatory Surgical Procedures
Fistula
Needles
Neoplasms
Necrosis
Epithelium
Temperature
Therapeutics

ASJC Scopus subject areas

  • Urology

Cite this

Patel, V. R., Leveillee, R. J., Hoey, M. F., Herron, A. J., Zaias, J., & Hulbert, J. C. (2000). Radiofrequency ablation of rabbit kidney using liquid electrode: Acute and chronic observations. Journal of Endourology, 14(2), 155-159.

Radiofrequency ablation of rabbit kidney using liquid electrode : Acute and chronic observations. / Patel, Vipul R.; Leveillee, Raymond J.; Hoey, Michael F.; Herron, Alan J.; Zaias, Julia; Hulbert, John C.

In: Journal of Endourology, Vol. 14, No. 2, 20.04.2000, p. 155-159.

Research output: Contribution to journalArticle

Patel, VR, Leveillee, RJ, Hoey, MF, Herron, AJ, Zaias, J & Hulbert, JC 2000, 'Radiofrequency ablation of rabbit kidney using liquid electrode: Acute and chronic observations', Journal of Endourology, vol. 14, no. 2, pp. 155-159.
Patel VR, Leveillee RJ, Hoey MF, Herron AJ, Zaias J, Hulbert JC. Radiofrequency ablation of rabbit kidney using liquid electrode: Acute and chronic observations. Journal of Endourology. 2000 Apr 20;14(2):155-159.
Patel, Vipul R. ; Leveillee, Raymond J. ; Hoey, Michael F. ; Herron, Alan J. ; Zaias, Julia ; Hulbert, John C. / Radiofrequency ablation of rabbit kidney using liquid electrode : Acute and chronic observations. In: Journal of Endourology. 2000 ; Vol. 14, No. 2. pp. 155-159.
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