Radioautographic localization of radioactivity in rat brain after intracarotid injection of 125I-α-melanocyte-stimulating hormone

Georges Pelletier; Fernand Labrie; Abba J. Kastin; Andrew V. Schally

doi:10.1016/0091-3057(75)90190-2

Radioautographic localization of radioactivity in rat brain after intracarotid injection of ¹²⁵I-α-melanocyte-stimulating hormone

Georges Pelletier, Fernand Labrie, Abba J. Kastin, Andrew V. Schally

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

¹²⁵I-α-melanocyte-stimulating hormone (MSH) was injected into the carotid artery of the rat and the radioactivity localized by radioautography. Radioactivity in the areas surrounding the ventricles and blood vessels after administration of ¹²⁵I-α-MSH but not ¹²⁵I-luteinizing hormone indicated passage of labeled material through the blood brain barrier. A specific concentration of radioactivity was found in the striatum and reticular nucleus of the thalamus. This localization, particularly in the thalamus, could be correlated with the previously reported effects of MSH on the brain of animals and man.

Original language	English (US)
Pages (from-to)	671-674
Number of pages	4
Journal	Pharmacology, Biochemistry and Behavior
Volume	3
Issue number	4
DOIs	https://doi.org/10.1016/0091-3057(75)90190-2
State	Published - 1975
Externally published	Yes

Keywords

Brain
Hormone
MSH
Peptide
Radioautography

ASJC Scopus subject areas

Biochemistry
Behavioral Neuroscience
Pharmacology

Access to Document

10.1016/0091-3057(75)90190-2

Cite this

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title = "Radioautographic localization of radioactivity in rat brain after intracarotid injection of 125I-α-melanocyte-stimulating hormone",

abstract = " 125I-α-melanocyte-stimulating hormone (MSH) was injected into the carotid artery of the rat and the radioactivity localized by radioautography. Radioactivity in the areas surrounding the ventricles and blood vessels after administration of 125I-α-MSH but not 125I-luteinizing hormone indicated passage of labeled material through the blood brain barrier. A specific concentration of radioactivity was found in the striatum and reticular nucleus of the thalamus. This localization, particularly in the thalamus, could be correlated with the previously reported effects of MSH on the brain of animals and man.",

keywords = "Brain, Hormone, MSH, Peptide, Radioautography",

author = "Georges Pelletier and Fernand Labrie and Kastin, {Abba J.} and Schally, {Andrew V.}",

note = "Funding Information: Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec, G1 V 4G2 Canada",

year = "1975",

doi = "10.1016/0091-3057(75)90190-2",

language = "English (US)",

volume = "3",

pages = "671--674",

journal = "Pharmacology Biochemistry and Behavior",

issn = "0091-3057",

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T1 - Radioautographic localization of radioactivity in rat brain after intracarotid injection of 125I-α-melanocyte-stimulating hormone

AU - Pelletier, Georges

AU - Labrie, Fernand

AU - Kastin, Abba J.

AU - Schally, Andrew V.

N1 - Funding Information: Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec, G1 V 4G2 Canada

PY - 1975

Y1 - 1975

N2 - 125I-α-melanocyte-stimulating hormone (MSH) was injected into the carotid artery of the rat and the radioactivity localized by radioautography. Radioactivity in the areas surrounding the ventricles and blood vessels after administration of 125I-α-MSH but not 125I-luteinizing hormone indicated passage of labeled material through the blood brain barrier. A specific concentration of radioactivity was found in the striatum and reticular nucleus of the thalamus. This localization, particularly in the thalamus, could be correlated with the previously reported effects of MSH on the brain of animals and man.

AB - 125I-α-melanocyte-stimulating hormone (MSH) was injected into the carotid artery of the rat and the radioactivity localized by radioautography. Radioactivity in the areas surrounding the ventricles and blood vessels after administration of 125I-α-MSH but not 125I-luteinizing hormone indicated passage of labeled material through the blood brain barrier. A specific concentration of radioactivity was found in the striatum and reticular nucleus of the thalamus. This localization, particularly in the thalamus, could be correlated with the previously reported effects of MSH on the brain of animals and man.

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KW - Hormone

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KW - Peptide

KW - Radioautography

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