Radical cystectomy for BCG failure: Has the timing improved in recent years?

Mark S. Soloway, David Hepps, Devendar Katkoori, Rajinikanth Ayyathurai, Murugesan Manoharan

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

OBJECTIVE To analyse if there is a trend in recent years towards performing radical cystectomy (RC) before muscle invasion or extravesical spread after failure of bacille Calmette-Guérin (BCG) for high grade Ta/T1 bladder cancer. Although BCG is indicated for prophylaxis after endoscopic tumour resection there is still a risk of progression. PATIENTS AND METHODS A retrospective analysis of our RC database (1992-2008) was performed to identify patients who underwent RC after receiving BCG. Relevant clinical and pathological data for the patients with clinical stage Ta, T1 and/or Tis at initial transurethral resection of bladder tumour were analysed. Pathological stage and survival for patients undergoing RC from 2003 to 2007 (group 2) were compared with those for patients operated between 1992 and 2002 (group 1). RESULTS A total of 152 patients were included (75 in group 2 and 77 in group 1). Both groups were similar in T-stage before BCG initiation, number of BCG cycles received and time interval to RC. There was no change in the proportion of patients undergoing RC with ≥pT2 bladder cancer in recent years (P= 0.5). Fifty-two percent of group 2 and 43% of group 1 had ≥pT2 BC. The 5-year survival was similar. CONCLUSIONS Despite concerns about delay in performing RC for patients failing one or more courses of BCG we have not observed a trend towards a lower pathological stage for patients undergoing RC after BCG. A high proportion of patients have muscle-invasive bladder cancer; more than 10% have lymph node metastasis.

Original languageEnglish (US)
Pages (from-to)182-185
Number of pages4
JournalBJU International
Volume108
Issue number2
DOIs
StatePublished - Jul 1 2011

Keywords

  • Bacille Calmette-Guérin
  • bladder cancer
  • cystectomy

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'Radical cystectomy for BCG failure: Has the timing improved in recent years?'. Together they form a unique fingerprint.

  • Cite this

    Soloway, M. S., Hepps, D., Katkoori, D., Ayyathurai, R., & Manoharan, M. (2011). Radical cystectomy for BCG failure: Has the timing improved in recent years? BJU International, 108(2), 182-185. https://doi.org/10.1111/j.1464-410X.2010.09830.x