Radiation protection and restoration by the synthetic 163-171 nonapeptide of human interleukin 1β

Daniela Frasca, S. Baschieri, D. Boraschi, A. Tagliabue, G. Doria

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We have previously reported that the synthetic nonapeptide VQGEESNDK, position 163-171 of human interleukin 1 (IL-1β), when injected in immunodepressed mice, shows immunorestorative activity similar to that of the whole protein, but with no IL-1-like inflammatory effects [Frasca et al., J. Immunol. 141, 2651-2655 (1988)]. In the present study we have compared the protective and restorative activities of the nonapeptide and human recombinant (hur) IL-1β on the survival of lethally irradiated mice. When mice were given a single injection of different doses of the nonapeptide or hurIL-1β 20 h before total-body irradiation, both molecules increased the percentage survival of mice exposed to 750 or 850 cGy, but not to 950 cGy. The nonapeptide, however, is less effective than hurIL-1β and displays a different dose-response relationship, suggesting that the two molecules act through different radioprotective pathways. When mice were injected with the nonapeptide or hurIL-1β immediately after exposure to 850 cGy, the percentage survival was also increased but restoration was lower than protection in both cases. The nonapeptide was also less effective than hurIL-1β in restoration, but the two molecules displayed a comparable dose-response relationship as if they shared similar mechanisms. These findings indicate that the 163-171 nonapeptide is able to protect from lethal radiation injury and to restore viability. The nonapeptide appears less effective than hurIL-1β but does not exhibit the IL-1-like side effects of the whole molecule.

Original languageEnglish
Pages (from-to)43-47
Number of pages5
JournalRadiation Research
Volume128
Issue number1
StatePublished - Nov 21 1991
Externally publishedYes

Fingerprint

interleukins
Radiation Protection
radiation protection
interleukin-1
Interleukin-1
restoration
mice
dosage
dose response
molecules
radiation injury
radiation injuries
Radiation Injuries
Survival
Whole-Body Irradiation
viability
Human Activities
irradiation
adverse effects
injection

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Biophysics
  • Radiation

Cite this

Frasca, D., Baschieri, S., Boraschi, D., Tagliabue, A., & Doria, G. (1991). Radiation protection and restoration by the synthetic 163-171 nonapeptide of human interleukin 1β. Radiation Research, 128(1), 43-47.

Radiation protection and restoration by the synthetic 163-171 nonapeptide of human interleukin 1β. / Frasca, Daniela; Baschieri, S.; Boraschi, D.; Tagliabue, A.; Doria, G.

In: Radiation Research, Vol. 128, No. 1, 21.11.1991, p. 43-47.

Research output: Contribution to journalArticle

Frasca, D, Baschieri, S, Boraschi, D, Tagliabue, A & Doria, G 1991, 'Radiation protection and restoration by the synthetic 163-171 nonapeptide of human interleukin 1β', Radiation Research, vol. 128, no. 1, pp. 43-47.
Frasca, Daniela ; Baschieri, S. ; Boraschi, D. ; Tagliabue, A. ; Doria, G. / Radiation protection and restoration by the synthetic 163-171 nonapeptide of human interleukin 1β. In: Radiation Research. 1991 ; Vol. 128, No. 1. pp. 43-47.
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