Radiation-induced meningiomas

Carolina Benjamin, Jugal K. Shah, Douglas Kondziolka

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Radiation-induced meningiomas (RIMs) became more common as the use of ionizing radiation was adopted in the treatment of medical conditions, both benign and malignant. Currently, RIMs represent the most common radiation-induced tumors. They are heterogeneous in terms of patient characteristics, radiographic appearance, genetics, pathology, symptoms, and management strategies. They tend to occur in a younger population and are generally more aggressive in nature than their spontaneous counterparts. Their characteristics also vary based on the dose of radiation received, which is most commonly separated into low dose (< 10 Gy) and high dose (> 10 Gy). The importance of the dosing classification is that it can provide insight into the nature and biologic behavior of the tumor. Given their heterogeneity, RIMs pose significant challenges in management. While surgical resection remains the preferred treatment when feasible, recent data supports stereotactic radiosurgery (SRS) as a comparable alternative. Although there is more knowledge about the molecular pathways leading to RIMs, targeted drug therapy is still limited and is the focus of current research.

Original languageEnglish (US)
Title of host publicationHandbook of Clinical Neurology
PublisherElsevier B.V.
Pages273-284
Number of pages12
DOIs
StatePublished - 2020
Externally publishedYes

Publication series

NameHandbook of Clinical Neurology
Volume169
ISSN (Print)0072-9752
ISSN (Electronic)2212-4152

Keywords

  • Meningioma
  • Radiation-induced meningioma
  • Radiation-induced neoplasm
  • Radiation-induced tumors
  • Radiosurgery, Surgical resection

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Radiation-induced meningiomas'. Together they form a unique fingerprint.

Cite this