Radiant energy during infrared neural stimulation at the target structure

Claus Peter Richter, Suhrud M Rajguru, Ryan Stafford, Stuart R. Stock

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Infrared neural stimulation (INS) describes a method, by which an infrared laser is used to stimulate neurons. The major benefit of INS over stimulating neurons with electrical current is its spatial selectivity. To translate the technique into a clinical application it is important to know the energy required to stimulate the neural structure. With this study we provide measurements of the radiant exposure, at the target structure that is required to stimulate the auditory neurons. Flat polished fibers were inserted into scala tympani so that the spiral ganglion was in front of the optical fiber. Angle polished fibers were inserted along scala tympani, and rotating the beveled surface of the fiber allowed the radiation beam to be directed perpendicular to the spiral ganglion. The radiant exposure for stimulation at the modiolus for flat and angle polished fibers averaged 6.78±2.15 mJ/cm2. With the angle polished fibers, a 90° change in the orientation of the optical beam from an orientation that resulted in an INS-evoked maximum response, resulted in a 50% drop in the response amplitude. When the orientation of the beam was changed by 180°, such that it was directed opposite to the orientation with the maxima, minimum response amplitude was observed.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8565
DOIs
StatePublished - May 30 2013
EventPhotonic Therapeutics and Diagnostics IX - San Francisco, CA, United States
Duration: Feb 2 2013Feb 7 2013

Other

OtherPhotonic Therapeutics and Diagnostics IX
CountryUnited States
CitySan Francisco, CA
Period2/2/132/7/13

Fingerprint

stimulation
Scala Tympani
Spiral Ganglion
Infrared radiation
Neurons
neurons
fibers
Fibers
radiation
Optical Fibers
Lasers
Radiation
Infrared lasers
infrared lasers
Optical fibers
optical fibers
selectivity
energy

Keywords

  • Cochlea
  • Hearing
  • Infrared neural stimulation
  • Laser
  • Optical stimulation

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Richter, C. P., Rajguru, S. M., Stafford, R., & Stock, S. R. (2013). Radiant energy during infrared neural stimulation at the target structure. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8565). [85655P] https://doi.org/10.1117/12.2013849

Radiant energy during infrared neural stimulation at the target structure. / Richter, Claus Peter; Rajguru, Suhrud M; Stafford, Ryan; Stock, Stuart R.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8565 2013. 85655P.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Richter, CP, Rajguru, SM, Stafford, R & Stock, SR 2013, Radiant energy during infrared neural stimulation at the target structure. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8565, 85655P, Photonic Therapeutics and Diagnostics IX, San Francisco, CA, United States, 2/2/13. https://doi.org/10.1117/12.2013849
Richter CP, Rajguru SM, Stafford R, Stock SR. Radiant energy during infrared neural stimulation at the target structure. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8565. 2013. 85655P https://doi.org/10.1117/12.2013849
Richter, Claus Peter ; Rajguru, Suhrud M ; Stafford, Ryan ; Stock, Stuart R. / Radiant energy during infrared neural stimulation at the target structure. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8565 2013.
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