Racial-ethnic disparities in the association between risk factors and diabetes: The Northern Manhattan Study

Erin R. Kulick, Yeseon P. Moon, Ken Cheung, Joshua Z. Willey, Ralph L Sacco, Mitchell S V Elkind

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Purpose: To identify risk factors (RF) for diabetes within a multiethnic cohort and to examine whether race-ethnicity modified their effects. Methods: Participants in the Northern Manhattan Study without diabetes at baseline were studied from 1993 to 2014 (n. =. 2430). Weibull regression models with interval censoring data were fit to calculate hazard ratios and 95% confidence intervals for incident diabetes. We tested for interactions between RF and race-ethnicity. Results: During a mean follow-up period of 11. years, there were 449 diagnoses of diabetes. Being non-Hispanic black (HR 1.69 95% CI 1.11-2.59) or Hispanic (HR 2.25 95% CI 1.48-3.40) versus non-Hispanic white, and body mass index (BMI; HR 1.34 per SD 95% CI 1.21-1.49) were associated with greater risk of diabetes; high-density lipoprotein cholesterol (HR 0.75 95% CI 0.66-0.86) was protective. There were interactions by race-ethnicity. In stratified models, the effects of BMI, current smoking, and C-reactive protein (CRP) on risk of diabetes differed by race-ethnicity (p for interaction

Original languageEnglish (US)
Pages (from-to)31-36
Number of pages6
JournalPreventive Medicine
Volume83
DOIs
StatePublished - Feb 1 2016

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Keywords

  • Diabetes mellitus
  • Epidemiology
  • Health status disparities
  • Risk factors
  • Urban health

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Epidemiology

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