Racial differences in adipocyte size and relationship to the metabolic syndrome in obese women

Thomas J. Tittelbach, Dora Berman-Weinberg, Barbara J. Nicklas, Alice S. Ryan, Andrew P. Goldberg

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective: To determine whether racial differences exist in the relationship of the abnormalities defining the metabolic syndrome (MS) to regional adiposity and fat cell size (FCS) in obese postmenopausal women. Research Methods and Procedures: We determined the relationship of metabolic variables associated with the MS to regional body composition and abdominal (ABD) and gluteal (GLT) FCS in 25 white (CAU) and 25 African-American (AF-AMER) older women matched for age (58 ± 5 years; mean ± SD) and BMI (35 ± 4 kg/m2). Results: MS was present in 36% of the AF-AMER and 57% of the CAU women. There were no differences in total body, trunk, gluteofemoral fat mass or regional FCS, but AF-AMER women had 22% lower visceral fat, 24% higher insulin, and 31% lower triglyceride levels than CAU women (p < 0.05). Multiple regression analysis with body fat, visceral ABD fat area, and FCS as independent variables showed that GLT FCS was independently correlated with 2-hour insulin (r = 0.56), triglyceride (r = 0.62), and high-density lipoprotein cholesterol (r = -0.72) levels in AF-AMER women but not in CAU women, where only systolic blood pressure correlated with subcutaneous ABD fat area (r = 0.57) (p < 0.05). Discussion: The associations between GLT FCS and metabolic dysfunction in obese AF-AMER but not CAU women suggest that central obesity is a less valid predictor of the MS in obese postmenopausal AF-AMER women than in CAU women and that GLT FCS may be a more sensitive indicator of risk for the MS in AF-AMER women.

Original languageEnglish
Pages (from-to)990-998
Number of pages9
JournalObesity Research
Volume12
Issue number6
StatePublished - Dec 1 2004

Fingerprint

metabolic syndrome
adipocytes
Adipocytes
African Americans
Cell Size
Intra-Abdominal Fat
abdominal fat
Triglycerides
insulin
triacylglycerols
Abdominal Subcutaneous Fat
Insulin
Blood Pressure
Abdominal Fat
visceral fat
Abdominal Obesity
Adiposity
systolic blood pressure
adiposity
research methods

Keywords

  • FCS
  • MS
  • Postmenopausal women
  • Race
  • Regional obesity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Tittelbach, T. J., Berman-Weinberg, D., Nicklas, B. J., Ryan, A. S., & Goldberg, A. P. (2004). Racial differences in adipocyte size and relationship to the metabolic syndrome in obese women. Obesity Research, 12(6), 990-998.

Racial differences in adipocyte size and relationship to the metabolic syndrome in obese women. / Tittelbach, Thomas J.; Berman-Weinberg, Dora; Nicklas, Barbara J.; Ryan, Alice S.; Goldberg, Andrew P.

In: Obesity Research, Vol. 12, No. 6, 01.12.2004, p. 990-998.

Research output: Contribution to journalArticle

Tittelbach, TJ, Berman-Weinberg, D, Nicklas, BJ, Ryan, AS & Goldberg, AP 2004, 'Racial differences in adipocyte size and relationship to the metabolic syndrome in obese women', Obesity Research, vol. 12, no. 6, pp. 990-998.
Tittelbach, Thomas J. ; Berman-Weinberg, Dora ; Nicklas, Barbara J. ; Ryan, Alice S. ; Goldberg, Andrew P. / Racial differences in adipocyte size and relationship to the metabolic syndrome in obese women. In: Obesity Research. 2004 ; Vol. 12, No. 6. pp. 990-998.
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