Abstract
Background: Racial-ethnic disparities exist in cardiovascular risk factors, morbidity, and mortality. Left ventricular diastolic dysfunction is a predictor of mortality and of cardiovascular outcome including incident heart failure. We sought to assess whether race-ethnic differences in diastolic function exist. Such differences may contribute to the observed disparities in cardiovascular outcomes. Methods: Two-dimensional echocardiography was performed in 760 participants (539 Hispanic, 117 non-Hispanic black, 104 non-Hispanic white) from the Cardiac Abnormalities and Brain Lesions study. Left ventricular diastolic function was assessed by standard Doppler flow profile and tissue Doppler imaging. Early (E) and late (A) transmitral diastolic flow, and mitral annulus early diastolic velocities (E′) were recorded; and E/A and E/E′ ratios were calculated. Results: Blacks and Hispanics had higher body mass index (P = .04, P < .01), higher prevalence of hypertension (both Ps ≤ .05) and diabetes (both Ps < .01), and lower level of education (both Ps < .01) compared with whites. In age- and sex-adjusted analyses, Hispanics and blacks showed worse indices of diastolic function than whites. Hispanics had lower E/A ratio (P = .01), lower E′, and higher E/E′ (both Ps < .01) than whites, whereas blacks had lower E′ (P < .05) and a trend toward a higher E/E′ ratio (P = .09) compared with whites. These race-ethnic differences in diastolic function were attenuated in multivariate models adjusted for cardiovascular risk factors. Conclusions: Differences in left ventricular diastolic function exist between race-ethnic groups. However, modifiable cardiovascular risk factors and sociodemographic variables, rather than intrinsic race-ethnic heterogeneity, seem to explain most of the observed differences.
| Original language | English |
|---|---|
| Pages (from-to) | 152-158 |
| Number of pages | 7 |
| Journal | American Heart Journal |
| Volume | 160 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 1 2010 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Race/ethnic disparities in left ventricular diastolic function in a triethnic community cohort. / Russo, Cesare; Jin, Zhezhen; Homma, Shunichi; Rundek, Tatjana; Elkind, Mitchell S V; Sacco, Ralph L; Di Tullio, Marco R.
In: American Heart Journal, Vol. 160, No. 1, 01.07.2010, p. 152-158.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Race/ethnic disparities in left ventricular diastolic function in a triethnic community cohort
AU - Russo, Cesare
AU - Jin, Zhezhen
AU - Homma, Shunichi
AU - Rundek, Tatjana
AU - Elkind, Mitchell S V
AU - Sacco, Ralph L
AU - Di Tullio, Marco R.
PY - 2010/7/1
Y1 - 2010/7/1
N2 - Background: Racial-ethnic disparities exist in cardiovascular risk factors, morbidity, and mortality. Left ventricular diastolic dysfunction is a predictor of mortality and of cardiovascular outcome including incident heart failure. We sought to assess whether race-ethnic differences in diastolic function exist. Such differences may contribute to the observed disparities in cardiovascular outcomes. Methods: Two-dimensional echocardiography was performed in 760 participants (539 Hispanic, 117 non-Hispanic black, 104 non-Hispanic white) from the Cardiac Abnormalities and Brain Lesions study. Left ventricular diastolic function was assessed by standard Doppler flow profile and tissue Doppler imaging. Early (E) and late (A) transmitral diastolic flow, and mitral annulus early diastolic velocities (E′) were recorded; and E/A and E/E′ ratios were calculated. Results: Blacks and Hispanics had higher body mass index (P = .04, P < .01), higher prevalence of hypertension (both Ps ≤ .05) and diabetes (both Ps < .01), and lower level of education (both Ps < .01) compared with whites. In age- and sex-adjusted analyses, Hispanics and blacks showed worse indices of diastolic function than whites. Hispanics had lower E/A ratio (P = .01), lower E′, and higher E/E′ (both Ps < .01) than whites, whereas blacks had lower E′ (P < .05) and a trend toward a higher E/E′ ratio (P = .09) compared with whites. These race-ethnic differences in diastolic function were attenuated in multivariate models adjusted for cardiovascular risk factors. Conclusions: Differences in left ventricular diastolic function exist between race-ethnic groups. However, modifiable cardiovascular risk factors and sociodemographic variables, rather than intrinsic race-ethnic heterogeneity, seem to explain most of the observed differences.
AB - Background: Racial-ethnic disparities exist in cardiovascular risk factors, morbidity, and mortality. Left ventricular diastolic dysfunction is a predictor of mortality and of cardiovascular outcome including incident heart failure. We sought to assess whether race-ethnic differences in diastolic function exist. Such differences may contribute to the observed disparities in cardiovascular outcomes. Methods: Two-dimensional echocardiography was performed in 760 participants (539 Hispanic, 117 non-Hispanic black, 104 non-Hispanic white) from the Cardiac Abnormalities and Brain Lesions study. Left ventricular diastolic function was assessed by standard Doppler flow profile and tissue Doppler imaging. Early (E) and late (A) transmitral diastolic flow, and mitral annulus early diastolic velocities (E′) were recorded; and E/A and E/E′ ratios were calculated. Results: Blacks and Hispanics had higher body mass index (P = .04, P < .01), higher prevalence of hypertension (both Ps ≤ .05) and diabetes (both Ps < .01), and lower level of education (both Ps < .01) compared with whites. In age- and sex-adjusted analyses, Hispanics and blacks showed worse indices of diastolic function than whites. Hispanics had lower E/A ratio (P = .01), lower E′, and higher E/E′ (both Ps < .01) than whites, whereas blacks had lower E′ (P < .05) and a trend toward a higher E/E′ ratio (P = .09) compared with whites. These race-ethnic differences in diastolic function were attenuated in multivariate models adjusted for cardiovascular risk factors. Conclusions: Differences in left ventricular diastolic function exist between race-ethnic groups. However, modifiable cardiovascular risk factors and sociodemographic variables, rather than intrinsic race-ethnic heterogeneity, seem to explain most of the observed differences.
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U2 - 10.1016/j.ahj.2010.04.010
DO - 10.1016/j.ahj.2010.04.010
M3 - Article
C2 - 20598986
AN - SCOPUS:77955699523
VL - 160
SP - 152
EP - 158
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 1
ER -