Race and ethnicity impact on the maximum proliferative response in peripheral blood lymphocytes from HIV-seropositive individuals

Michael A Kolber, M. O. Saenz, Orlando W Gomez-Marin, Leonardo Tamariz

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Summary: The effects of race and ethnicity on immunological function have not been fully studied in patients infected with HIV-1. To study such differences, 54 patients on virally suppressive highly active antiretroviral therapy (HAART) with CD4 counts >200cells/μL had their peripheral blood lymphocytes (PBL) evaluated for response to recall antigen. Significant differences were found in the maximum responses for PBL from black individuals compared with those from white individuals, and the differences were highly significant when responses for African-Americans were compared with those for white-Hispanics. These findings support work delineating ethnicity and race as significant variables to be taken into account when looking at vaccination strategies and responsiveness to therapeutic pharmacological interventions.

Original languageEnglish
Pages (from-to)401-405
Number of pages5
JournalHIV Medicine
Volume8
Issue number6
DOIs
StatePublished - Sep 1 2007

Fingerprint

HIV
Lymphocytes
Highly Active Antiretroviral Therapy
CD4 Lymphocyte Count
Hispanic Americans
Individuality
African Americans
HIV-1
Vaccination
Pharmacology
Antigens
Therapeutics

Keywords

  • Ethnicity
  • HIV/AIDS
  • Proliferation
  • Race

ASJC Scopus subject areas

  • Virology
  • Medicine(all)
  • Immunology

Cite this

Race and ethnicity impact on the maximum proliferative response in peripheral blood lymphocytes from HIV-seropositive individuals. / Kolber, Michael A; Saenz, M. O.; Gomez-Marin, Orlando W; Tamariz, Leonardo.

In: HIV Medicine, Vol. 8, No. 6, 01.09.2007, p. 401-405.

Research output: Contribution to journalArticle

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