Abstract
Summary: The effects of race and ethnicity on immunological function have not been fully studied in patients infected with HIV-1. To study such differences, 54 patients on virally suppressive highly active antiretroviral therapy (HAART) with CD4 counts >200cells/μL had their peripheral blood lymphocytes (PBL) evaluated for response to recall antigen. Significant differences were found in the maximum responses for PBL from black individuals compared with those from white individuals, and the differences were highly significant when responses for African-Americans were compared with those for white-Hispanics. These findings support work delineating ethnicity and race as significant variables to be taken into account when looking at vaccination strategies and responsiveness to therapeutic pharmacological interventions.
| Original language | English |
|---|---|
| Pages (from-to) | 401-405 |
| Number of pages | 5 |
| Journal | HIV Medicine |
| Volume | 8 |
| Issue number | 6 |
| DOIs | |
| State | Published - Sep 1 2007 |
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Keywords
- Ethnicity
- HIV/AIDS
- Proliferation
- Race
ASJC Scopus subject areas
- Virology
- Medicine(all)
- Immunology
Cite this
Race and ethnicity impact on the maximum proliferative response in peripheral blood lymphocytes from HIV-seropositive individuals. / Kolber, Michael A; Saenz, M. O.; Gomez-Marin, Orlando W; Tamariz, Leonardo.
In: HIV Medicine, Vol. 8, No. 6, 01.09.2007, p. 401-405.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Race and ethnicity impact on the maximum proliferative response in peripheral blood lymphocytes from HIV-seropositive individuals
AU - Kolber, Michael A
AU - Saenz, M. O.
AU - Gomez-Marin, Orlando W
AU - Tamariz, Leonardo
PY - 2007/9/1
Y1 - 2007/9/1
N2 - Summary: The effects of race and ethnicity on immunological function have not been fully studied in patients infected with HIV-1. To study such differences, 54 patients on virally suppressive highly active antiretroviral therapy (HAART) with CD4 counts >200cells/μL had their peripheral blood lymphocytes (PBL) evaluated for response to recall antigen. Significant differences were found in the maximum responses for PBL from black individuals compared with those from white individuals, and the differences were highly significant when responses for African-Americans were compared with those for white-Hispanics. These findings support work delineating ethnicity and race as significant variables to be taken into account when looking at vaccination strategies and responsiveness to therapeutic pharmacological interventions.
AB - Summary: The effects of race and ethnicity on immunological function have not been fully studied in patients infected with HIV-1. To study such differences, 54 patients on virally suppressive highly active antiretroviral therapy (HAART) with CD4 counts >200cells/μL had their peripheral blood lymphocytes (PBL) evaluated for response to recall antigen. Significant differences were found in the maximum responses for PBL from black individuals compared with those from white individuals, and the differences were highly significant when responses for African-Americans were compared with those for white-Hispanics. These findings support work delineating ethnicity and race as significant variables to be taken into account when looking at vaccination strategies and responsiveness to therapeutic pharmacological interventions.
KW - Ethnicity
KW - HIV/AIDS
KW - Proliferation
KW - Race
UR - http://www.scopus.com/inward/record.url?scp=34547406134&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34547406134&partnerID=8YFLogxK
U2 - 10.1111/j.1468-1293.2007.00479.x
DO - 10.1111/j.1468-1293.2007.00479.x
M3 - Article
C2 - 17661849
AN - SCOPUS:34547406134
VL - 8
SP - 401
EP - 405
JO - HIV Medicine
JF - HIV Medicine
SN - 1464-2662
IS - 6
ER -