Rabbit tissue reaction to several implant biomaterials

H. Kato, J. M. Parel, V. Jallet, H. Kondo, D. Budenz, Y. Pouliquen

Research output: Contribution to journalArticlepeer-review


Purpose : To investigate the safety of a polytetrafîuoroethylene (PTFE) implant developed for a novel glaucoma implant (MESH), the biocompatibility for several materials were compared. Methods: 2 types of PTFE implants with or without nucropores. and implants made of dacron (PET) and silastic (PDMS) materials were inserted suhconjunciivally through a 3.2mm transcorneoscleral paracentesis in 25 rabbits Rabbits were sacrified at postoperative day (POD) 3, 7, 14, 21, 28 and examined by light and electron microscopy. The type of inflammatory cells and appearence of MHC-1 and MHC-2 were analysed using immunohistochemistry. Results With PTFE, a few neutrophils and macrophages were noted at POD 3, but they rapidly disappeared with time. A similar reaction was observed with PDMS, but the macrophages remained throughout the experiment period. With PET, a large number of neutrophils and macrophages were observed at POD 3 and many lymphocyte infiltrates appeared betweeen POD 14 and 28. T-lymphocytes were found solely on PET implanted animals. MHC-1 was detected on PDMS and PET but not on PTFE implanted rabbits. MHC-2 was detected at all periods in PDMS and PHT animals, but in a decreasing amount with PTFE. Cpnc)usion: Silastic and Dacron induce a higher immuno-reaction than Teflon. Thus far, pure PTFE is the best material for the MESH and. potentially, for other glaucoma filtration implants.

Original languageEnglish (US)
Pages (from-to)S269
JournalInvestigative Ophthalmology and Visual Science
Issue number4
StatePublished - 1997

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Rabbit tissue reaction to several implant biomaterials'. Together they form a unique fingerprint.

Cite this