Quantitative PCR-based screening of α-synuclein multiplication in multiple system atrophy

Sarah J. Lincoln, Owen A. Ross, Nicole M. Milkovic, Dennis W. Dickson, Alex Rajput, Christopher A. Robinson, Spiridon Papapetropoulos, Deborah C. Mash, Matthew J. Farrer

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Multiple system atrophy (MSA) is by nature a 'sporadic' disease with no evidence of familial aggregation observed. However, the α-synuclein locus (SNCA) multiplication families have clinically displayed parkinsonism and autonomic dysfunction. The present study did not find any SNCA multiplications in a series of 58 pathologically confirmed MSA cases excluding this event as a common cause of MSA. The question of a genetic component in MSA remains to be answered.

Original languageEnglish (US)
Pages (from-to)340-342
Number of pages3
JournalParkinsonism and Related Disorders
Volume13
Issue number6
DOIs
StatePublished - Aug 1 2007

Keywords

  • α-Synuclein
  • Genomic multiplication
  • Multiple system atrophy
  • Quantitative PCR

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Neurology

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    Lincoln, S. J., Ross, O. A., Milkovic, N. M., Dickson, D. W., Rajput, A., Robinson, C. A., Papapetropoulos, S., Mash, D. C., & Farrer, M. J. (2007). Quantitative PCR-based screening of α-synuclein multiplication in multiple system atrophy. Parkinsonism and Related Disorders, 13(6), 340-342. https://doi.org/10.1016/j.parkreldis.2006.12.005