Quantitative morphometric study of muscle in inclusion body myositis

Ashok Verma, Walter G Bradley, N. W. Soule, W. W. Pendlebury, J. Kelly, L. S. Adelman, S. M. Chou, G. Karpati, J. F. Brenner

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Clinical and electromyographic findings do not clearly distinguish body myositis (IBM) from chronic polymyositis (PM). The rimmed vacuoles and filamentous nuclear and cytoplasmic inclusions that characterize IBM are often sparse and may be overlooked; conversely, these features may occasionally be seen in other diseases. Preliminary studies suggested that muscle fiber hypertrophy occured more frequently in IBM than in PM. To investigate whether fiber hypertrophy can be used to improve the ability to separate IBM from PM, we report a morphometric analysis of 28 IBM cases, 22 PM and 22 dermatomyositis (DM) cases. The analysis, using a computer automated system, included proportion of hypertrophied fibers and also fiber type proportions, average fiber diameter, proportion of atrophic and angulated fibers, and the co-dispersion index (CDI). The proportion of hypertrophied fibers was greater in IBM than the other two conditions (IBM(mean ± SEM) 31.0 ± 4.7% and 12.2 ± 2.4% for type 1 and type 2 fibers, respectively, compared to 9.8 ± 3.0% and 3.3 ± 1.7% in PM, and 7.7 ± 2.7% and 3.9 ± 1.9% in DM). These differences were statistically significant (P < 0.05) in both sexes for type 1 fibers and in women for type 2 fibers. Also, the average fiber size and hypertrophy factors for type 1 and type 2 fibers were increased in IBM compared to PM and DM. This study confirms that the presence of muscle fiber hypertrophy in biopsies from IBM patients may help differentiate them from other clinically similar inflammatory myopathies.

Original languageEnglish
Pages (from-to)192-198
Number of pages7
JournalJournal of the Neurological Sciences
Volume112
Issue number1-2
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

Inclusion Body Myositis
Polymyositis
Hypertrophy
Dermatomyositis
Muscles
Myositis
Intranuclear Inclusion Bodies
Inclusion Bodies
Computer Systems
Vacuoles
Biopsy

Keywords

  • Dermatomyositis
  • Inclusion body myositis
  • Morphometry
  • Muscle fiber hypertrophy
  • Polymyositis

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

Quantitative morphometric study of muscle in inclusion body myositis. / Verma, Ashok; Bradley, Walter G; Soule, N. W.; Pendlebury, W. W.; Kelly, J.; Adelman, L. S.; Chou, S. M.; Karpati, G.; Brenner, J. F.

In: Journal of the Neurological Sciences, Vol. 112, No. 1-2, 01.01.1992, p. 192-198.

Research output: Contribution to journalArticle

Verma, A, Bradley, WG, Soule, NW, Pendlebury, WW, Kelly, J, Adelman, LS, Chou, SM, Karpati, G & Brenner, JF 1992, 'Quantitative morphometric study of muscle in inclusion body myositis', Journal of the Neurological Sciences, vol. 112, no. 1-2, pp. 192-198. https://doi.org/10.1016/0022-510X(92)90150-J
Verma, Ashok ; Bradley, Walter G ; Soule, N. W. ; Pendlebury, W. W. ; Kelly, J. ; Adelman, L. S. ; Chou, S. M. ; Karpati, G. ; Brenner, J. F. / Quantitative morphometric study of muscle in inclusion body myositis. In: Journal of the Neurological Sciences. 1992 ; Vol. 112, No. 1-2. pp. 192-198.
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