Abstract
Clinical and electromyographic findings do not clearly distinguish body myositis (IBM) from chronic polymyositis (PM). The rimmed vacuoles and filamentous nuclear and cytoplasmic inclusions that characterize IBM are often sparse and may be overlooked; conversely, these features may occasionally be seen in other diseases. Preliminary studies suggested that muscle fiber hypertrophy occured more frequently in IBM than in PM. To investigate whether fiber hypertrophy can be used to improve the ability to separate IBM from PM, we report a morphometric analysis of 28 IBM cases, 22 PM and 22 dermatomyositis (DM) cases. The analysis, using a computer automated system, included proportion of hypertrophied fibers and also fiber type proportions, average fiber diameter, proportion of atrophic and angulated fibers, and the co-dispersion index (CDI). The proportion of hypertrophied fibers was greater in IBM than the other two conditions (IBM(mean ± SEM) 31.0 ± 4.7% and 12.2 ± 2.4% for type 1 and type 2 fibers, respectively, compared to 9.8 ± 3.0% and 3.3 ± 1.7% in PM, and 7.7 ± 2.7% and 3.9 ± 1.9% in DM). These differences were statistically significant (P < 0.05) in both sexes for type 1 fibers and in women for type 2 fibers. Also, the average fiber size and hypertrophy factors for type 1 and type 2 fibers were increased in IBM compared to PM and DM. This study confirms that the presence of muscle fiber hypertrophy in biopsies from IBM patients may help differentiate them from other clinically similar inflammatory myopathies.
| Original language | English |
|---|---|
| Pages (from-to) | 192-198 |
| Number of pages | 7 |
| Journal | Journal of the Neurological Sciences |
| Volume | 112 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Jan 1 1992 |
| Externally published | Yes |
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Keywords
- Dermatomyositis
- Inclusion body myositis
- Morphometry
- Muscle fiber hypertrophy
- Polymyositis
ASJC Scopus subject areas
- Aging
- Clinical Neurology
- Surgery
- Neuroscience(all)
- Developmental Neuroscience
- Neurology
Cite this
Quantitative morphometric study of muscle in inclusion body myositis. / Verma, Ashok; Bradley, Walter G; Soule, N. W.; Pendlebury, W. W.; Kelly, J.; Adelman, L. S.; Chou, S. M.; Karpati, G.; Brenner, J. F.
In: Journal of the Neurological Sciences, Vol. 112, No. 1-2, 01.01.1992, p. 192-198.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Quantitative morphometric study of muscle in inclusion body myositis
AU - Verma, Ashok
AU - Bradley, Walter G
AU - Soule, N. W.
AU - Pendlebury, W. W.
AU - Kelly, J.
AU - Adelman, L. S.
AU - Chou, S. M.
AU - Karpati, G.
AU - Brenner, J. F.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - Clinical and electromyographic findings do not clearly distinguish body myositis (IBM) from chronic polymyositis (PM). The rimmed vacuoles and filamentous nuclear and cytoplasmic inclusions that characterize IBM are often sparse and may be overlooked; conversely, these features may occasionally be seen in other diseases. Preliminary studies suggested that muscle fiber hypertrophy occured more frequently in IBM than in PM. To investigate whether fiber hypertrophy can be used to improve the ability to separate IBM from PM, we report a morphometric analysis of 28 IBM cases, 22 PM and 22 dermatomyositis (DM) cases. The analysis, using a computer automated system, included proportion of hypertrophied fibers and also fiber type proportions, average fiber diameter, proportion of atrophic and angulated fibers, and the co-dispersion index (CDI). The proportion of hypertrophied fibers was greater in IBM than the other two conditions (IBM(mean ± SEM) 31.0 ± 4.7% and 12.2 ± 2.4% for type 1 and type 2 fibers, respectively, compared to 9.8 ± 3.0% and 3.3 ± 1.7% in PM, and 7.7 ± 2.7% and 3.9 ± 1.9% in DM). These differences were statistically significant (P < 0.05) in both sexes for type 1 fibers and in women for type 2 fibers. Also, the average fiber size and hypertrophy factors for type 1 and type 2 fibers were increased in IBM compared to PM and DM. This study confirms that the presence of muscle fiber hypertrophy in biopsies from IBM patients may help differentiate them from other clinically similar inflammatory myopathies.
AB - Clinical and electromyographic findings do not clearly distinguish body myositis (IBM) from chronic polymyositis (PM). The rimmed vacuoles and filamentous nuclear and cytoplasmic inclusions that characterize IBM are often sparse and may be overlooked; conversely, these features may occasionally be seen in other diseases. Preliminary studies suggested that muscle fiber hypertrophy occured more frequently in IBM than in PM. To investigate whether fiber hypertrophy can be used to improve the ability to separate IBM from PM, we report a morphometric analysis of 28 IBM cases, 22 PM and 22 dermatomyositis (DM) cases. The analysis, using a computer automated system, included proportion of hypertrophied fibers and also fiber type proportions, average fiber diameter, proportion of atrophic and angulated fibers, and the co-dispersion index (CDI). The proportion of hypertrophied fibers was greater in IBM than the other two conditions (IBM(mean ± SEM) 31.0 ± 4.7% and 12.2 ± 2.4% for type 1 and type 2 fibers, respectively, compared to 9.8 ± 3.0% and 3.3 ± 1.7% in PM, and 7.7 ± 2.7% and 3.9 ± 1.9% in DM). These differences were statistically significant (P < 0.05) in both sexes for type 1 fibers and in women for type 2 fibers. Also, the average fiber size and hypertrophy factors for type 1 and type 2 fibers were increased in IBM compared to PM and DM. This study confirms that the presence of muscle fiber hypertrophy in biopsies from IBM patients may help differentiate them from other clinically similar inflammatory myopathies.
KW - Dermatomyositis
KW - Inclusion body myositis
KW - Morphometry
KW - Muscle fiber hypertrophy
KW - Polymyositis
UR - http://www.scopus.com/inward/record.url?scp=0026438066&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026438066&partnerID=8YFLogxK
U2 - 10.1016/0022-510X(92)90150-J
DO - 10.1016/0022-510X(92)90150-J
M3 - Article
C2 - 1335036
AN - SCOPUS:0026438066
VL - 112
SP - 192
EP - 198
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
SN - 0022-510X
IS - 1-2
ER -