Quantitative measurement of histamine H1 receptors in human brains by PET and [11C]doxepin

Hideki Mochizuki, Yuichi Kimura, Kenji Ishii, Keiichi Oda, Toru Sasaki, Manabu Tashiro, Kazuhiko Yanai, Kiichi Ishiwata

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The aim of this study is to establish a method for quantitative measurement of histamine H1 receptor (H1R) in human brain by PET and [11C]doxepin ([11C]DOX). The estimated parameters with a two-compartment model were stable for the initial values for parameter estimation but those with a three-compartment model were not. This finding suggests that the H1R measured by the [11C]DOX and PET can be evaluated with a two-compartment model.

Original languageEnglish (US)
Pages (from-to)165-171
Number of pages7
JournalNuclear Medicine and Biology
Volume31
Issue number2
DOIs
StatePublished - Feb 1 2004
Externally publishedYes

Keywords

  • Compartment model
  • Histamine H receptor
  • PET
  • [ C]doxepin

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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