Quantitative measurement of histamine H1 receptors in human brains by PET and [11C]doxepin

Hideki Mochizuki, Yuichi Kimura, Kenji Ishii, Keiichi Oda, Toru Sasaki, Manabu Tashiro, Kazuhiko Yanai, Kiichi Ishiwata

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The aim of this study is to establish a method for quantitative measurement of histamine H1 receptor (H1R) in human brain by PET and [11C]doxepin ([11C]DOX). The estimated parameters with a two-compartment model were stable for the initial values for parameter estimation but those with a three-compartment model were not. This finding suggests that the H1R measured by the [11C]DOX and PET can be evaluated with a two-compartment model.

Original languageEnglish (US)
Pages (from-to)165-171
Number of pages7
JournalNuclear Medicine and Biology
Volume31
Issue number2
DOIs
StatePublished - Feb 1 2004
Externally publishedYes

Fingerprint

Doxepin
Histamine H1 Receptors
Brain

Keywords

  • [ C]doxepin
  • Compartment model
  • Histamine H receptor
  • PET

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Quantitative measurement of histamine H1 receptors in human brains by PET and [11C]doxepin. / Mochizuki, Hideki; Kimura, Yuichi; Ishii, Kenji; Oda, Keiichi; Sasaki, Toru; Tashiro, Manabu; Yanai, Kazuhiko; Ishiwata, Kiichi.

In: Nuclear Medicine and Biology, Vol. 31, No. 2, 01.02.2004, p. 165-171.

Research output: Contribution to journalArticle

Mochizuki, H, Kimura, Y, Ishii, K, Oda, K, Sasaki, T, Tashiro, M, Yanai, K & Ishiwata, K 2004, 'Quantitative measurement of histamine H1 receptors in human brains by PET and [11C]doxepin', Nuclear Medicine and Biology, vol. 31, no. 2, pp. 165-171. https://doi.org/10.1016/j.nucmedbio.2003.08.010
Mochizuki, Hideki ; Kimura, Yuichi ; Ishii, Kenji ; Oda, Keiichi ; Sasaki, Toru ; Tashiro, Manabu ; Yanai, Kazuhiko ; Ishiwata, Kiichi. / Quantitative measurement of histamine H1 receptors in human brains by PET and [11C]doxepin. In: Nuclear Medicine and Biology. 2004 ; Vol. 31, No. 2. pp. 165-171.
@article{ca623d34faf4409090a0d9bc86645f79,
title = "Quantitative measurement of histamine H1 receptors in human brains by PET and [11C]doxepin",
abstract = "The aim of this study is to establish a method for quantitative measurement of histamine H1 receptor (H1R) in human brain by PET and [11C]doxepin ([11C]DOX). The estimated parameters with a two-compartment model were stable for the initial values for parameter estimation but those with a three-compartment model were not. This finding suggests that the H1R measured by the [11C]DOX and PET can be evaluated with a two-compartment model.",
keywords = "[ C]doxepin, Compartment model, Histamine H receptor, PET",
author = "Hideki Mochizuki and Yuichi Kimura and Kenji Ishii and Keiichi Oda and Toru Sasaki and Manabu Tashiro and Kazuhiko Yanai and Kiichi Ishiwata",
year = "2004",
month = "2",
day = "1",
doi = "10.1016/j.nucmedbio.2003.08.010",
language = "English (US)",
volume = "31",
pages = "165--171",
journal = "Nuclear Medicine and Biology",
issn = "0969-8051",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Quantitative measurement of histamine H1 receptors in human brains by PET and [11C]doxepin

AU - Mochizuki, Hideki

AU - Kimura, Yuichi

AU - Ishii, Kenji

AU - Oda, Keiichi

AU - Sasaki, Toru

AU - Tashiro, Manabu

AU - Yanai, Kazuhiko

AU - Ishiwata, Kiichi

PY - 2004/2/1

Y1 - 2004/2/1

N2 - The aim of this study is to establish a method for quantitative measurement of histamine H1 receptor (H1R) in human brain by PET and [11C]doxepin ([11C]DOX). The estimated parameters with a two-compartment model were stable for the initial values for parameter estimation but those with a three-compartment model were not. This finding suggests that the H1R measured by the [11C]DOX and PET can be evaluated with a two-compartment model.

AB - The aim of this study is to establish a method for quantitative measurement of histamine H1 receptor (H1R) in human brain by PET and [11C]doxepin ([11C]DOX). The estimated parameters with a two-compartment model were stable for the initial values for parameter estimation but those with a three-compartment model were not. This finding suggests that the H1R measured by the [11C]DOX and PET can be evaluated with a two-compartment model.

KW - [ C]doxepin

KW - Compartment model

KW - Histamine H receptor

KW - PET

UR - http://www.scopus.com/inward/record.url?scp=1542345729&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1542345729&partnerID=8YFLogxK

U2 - 10.1016/j.nucmedbio.2003.08.010

DO - 10.1016/j.nucmedbio.2003.08.010

M3 - Article

C2 - 15013481

AN - SCOPUS:1542345729

VL - 31

SP - 165

EP - 171

JO - Nuclear Medicine and Biology

JF - Nuclear Medicine and Biology

SN - 0969-8051

IS - 2

ER -