Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography

Zhongdi Chu, Jason Lin, Chen Gao, Chen Xin, Qinqin Zhang, Chieh Li Chen, Luis Roisman, Giovanni Gregori, Philip J. Rosenfeld, Ruikang K. Wang

Research output: Contribution to journalArticlepeer-review

126 Scopus citations


Optical coherence tomography angiography (OCTA) is clinically useful for the qualitative assessment of the macular microvasculature. However, there is a need for comprehensive quantitative tools to help objectively analyze the OCT angiograms. Few studies have reported the use of a single quantitative index to describe vessel density in OCT angiograms. In this study, we introduce a five-index quantitative analysis of OCT angiograms in an attempt to detect and assess vascular abnormalities from multiple perspectives. The indices include vessel area density, vessel skeleton density, vessel diameter index, vessel perimeter index, and vessel complexity index. We show the usefulness of the proposed indices with five illustrative cases. Repeatability is tested on both a healthy case and a stable diseased case, giving interclass coefficients smaller than 0.031. The results demonstrate that our proposed quantitative analysis may be useful as a complement to conventional OCTA for the diagnosis of disease and monitoring of treatment.

Original languageEnglish (US)
Article number066008
JournalJournal of Biomedical Optics
Issue number6
StatePublished - Jun 1 2016


  • optical coherence tomography
  • optical coherence tomography angiography
  • vascular quantification
  • vessel area density
  • vessel complexity index
  • vessel diameter index
  • vessel perimeter index
  • vessel skeleton density

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering


Dive into the research topics of 'Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography'. Together they form a unique fingerprint.

Cite this