Quantitative analysis of the effects of physiologic brain motion on point-resolved spectroscopy

Pradip Pattany, M. G. Massand, B. C. Bowen, Robert Quencer

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: Although single-voxel proton MR spectroscopy is a noninvasive method that enables measurement of brain metabolite concentrations, it has been shown that physiologic brain motion causes inaccuracies in measurement of metabolite concentrations and increases the overall SD of the measurements when the stimulated echo acquisition mode (STEAM) is used. We tested the hypothesis that the point-resolved spectroscopy (PRESS) technique is less sensitive to physiologic brain motion than the STEAM technique. METHODS: In 10 healthy subjects, spectra were obtained from a voxel located in the left basal ganglia by using the PRESS sequence with cardiac gating and without water suppression to assess global phase change as a function of physiologic brain motion. This was accomplished by acquiring data at various time delays from the R wave throughout the cardiac cycle. Subsequently, spectra were obtained in 10 healthy subjects by using PRESS both without and with cardiac gating, and with water suppression, to determine whether brain motion resulted in a statistically significant difference in mean and SD of measured metabolite concentration. RESULTS: At various time delays from the R wave throughout the cardiac cycle, no significant global phase difference was noted in water signal intensity. In addition, when PRESS data were obtained both without and with cardiac gating (by using an optimal delay obtained from previously published data by using STEAM), no significant difference was seen in measured metabolite concentrations and SDs. CONCLUSION: The PRESS technique is relatively insensitive to physiologic brain motion.

Original languageEnglish
Pages (from-to)1070-1073
Number of pages4
JournalAmerican Journal of Neuroradiology
Volume27
Issue number5
StatePublished - May 1 2006

Fingerprint

Spectrum Analysis
Brain
Water
Healthy Volunteers
Basal Ganglia
Protons
Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Quantitative analysis of the effects of physiologic brain motion on point-resolved spectroscopy. / Pattany, Pradip; Massand, M. G.; Bowen, B. C.; Quencer, Robert.

In: American Journal of Neuroradiology, Vol. 27, No. 5, 01.05.2006, p. 1070-1073.

Research output: Contribution to journalArticle

@article{3bac08bcf03a41c59de071ec81819a91,
title = "Quantitative analysis of the effects of physiologic brain motion on point-resolved spectroscopy",
abstract = "BACKGROUND AND PURPOSE: Although single-voxel proton MR spectroscopy is a noninvasive method that enables measurement of brain metabolite concentrations, it has been shown that physiologic brain motion causes inaccuracies in measurement of metabolite concentrations and increases the overall SD of the measurements when the stimulated echo acquisition mode (STEAM) is used. We tested the hypothesis that the point-resolved spectroscopy (PRESS) technique is less sensitive to physiologic brain motion than the STEAM technique. METHODS: In 10 healthy subjects, spectra were obtained from a voxel located in the left basal ganglia by using the PRESS sequence with cardiac gating and without water suppression to assess global phase change as a function of physiologic brain motion. This was accomplished by acquiring data at various time delays from the R wave throughout the cardiac cycle. Subsequently, spectra were obtained in 10 healthy subjects by using PRESS both without and with cardiac gating, and with water suppression, to determine whether brain motion resulted in a statistically significant difference in mean and SD of measured metabolite concentration. RESULTS: At various time delays from the R wave throughout the cardiac cycle, no significant global phase difference was noted in water signal intensity. In addition, when PRESS data were obtained both without and with cardiac gating (by using an optimal delay obtained from previously published data by using STEAM), no significant difference was seen in measured metabolite concentrations and SDs. CONCLUSION: The PRESS technique is relatively insensitive to physiologic brain motion.",
author = "Pradip Pattany and Massand, {M. G.} and Bowen, {B. C.} and Robert Quencer",
year = "2006",
month = "5",
day = "1",
language = "English",
volume = "27",
pages = "1070--1073",
journal = "American Journal of Neuroradiology",
issn = "0195-6108",
publisher = "American Society of Neuroradiology",
number = "5",

}

TY - JOUR

T1 - Quantitative analysis of the effects of physiologic brain motion on point-resolved spectroscopy

AU - Pattany, Pradip

AU - Massand, M. G.

AU - Bowen, B. C.

AU - Quencer, Robert

PY - 2006/5/1

Y1 - 2006/5/1

N2 - BACKGROUND AND PURPOSE: Although single-voxel proton MR spectroscopy is a noninvasive method that enables measurement of brain metabolite concentrations, it has been shown that physiologic brain motion causes inaccuracies in measurement of metabolite concentrations and increases the overall SD of the measurements when the stimulated echo acquisition mode (STEAM) is used. We tested the hypothesis that the point-resolved spectroscopy (PRESS) technique is less sensitive to physiologic brain motion than the STEAM technique. METHODS: In 10 healthy subjects, spectra were obtained from a voxel located in the left basal ganglia by using the PRESS sequence with cardiac gating and without water suppression to assess global phase change as a function of physiologic brain motion. This was accomplished by acquiring data at various time delays from the R wave throughout the cardiac cycle. Subsequently, spectra were obtained in 10 healthy subjects by using PRESS both without and with cardiac gating, and with water suppression, to determine whether brain motion resulted in a statistically significant difference in mean and SD of measured metabolite concentration. RESULTS: At various time delays from the R wave throughout the cardiac cycle, no significant global phase difference was noted in water signal intensity. In addition, when PRESS data were obtained both without and with cardiac gating (by using an optimal delay obtained from previously published data by using STEAM), no significant difference was seen in measured metabolite concentrations and SDs. CONCLUSION: The PRESS technique is relatively insensitive to physiologic brain motion.

AB - BACKGROUND AND PURPOSE: Although single-voxel proton MR spectroscopy is a noninvasive method that enables measurement of brain metabolite concentrations, it has been shown that physiologic brain motion causes inaccuracies in measurement of metabolite concentrations and increases the overall SD of the measurements when the stimulated echo acquisition mode (STEAM) is used. We tested the hypothesis that the point-resolved spectroscopy (PRESS) technique is less sensitive to physiologic brain motion than the STEAM technique. METHODS: In 10 healthy subjects, spectra were obtained from a voxel located in the left basal ganglia by using the PRESS sequence with cardiac gating and without water suppression to assess global phase change as a function of physiologic brain motion. This was accomplished by acquiring data at various time delays from the R wave throughout the cardiac cycle. Subsequently, spectra were obtained in 10 healthy subjects by using PRESS both without and with cardiac gating, and with water suppression, to determine whether brain motion resulted in a statistically significant difference in mean and SD of measured metabolite concentration. RESULTS: At various time delays from the R wave throughout the cardiac cycle, no significant global phase difference was noted in water signal intensity. In addition, when PRESS data were obtained both without and with cardiac gating (by using an optimal delay obtained from previously published data by using STEAM), no significant difference was seen in measured metabolite concentrations and SDs. CONCLUSION: The PRESS technique is relatively insensitive to physiologic brain motion.

UR - http://www.scopus.com/inward/record.url?scp=33750578632&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750578632&partnerID=8YFLogxK

M3 - Article

C2 - 16687544

AN - SCOPUS:33750578632

VL - 27

SP - 1070

EP - 1073

JO - American Journal of Neuroradiology

JF - American Journal of Neuroradiology

SN - 0195-6108

IS - 5

ER -