Quantitation of S100 protein-positive cells in inflamed and non-inflamed keratoacanthoma and squamous cell carcinoma

R. Korenberg, N. S. Penneys, A. Kowalczyk, Mehrdad Nadji

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Langerhans cells (LC) were identified and quantitated in non-inflamed keratoacanthoma (KA), inflamed KA, non-inflamed squamous cell carcinoma (SCC), and inflamed SCC, by their content of S100 protein. The number of LCs per high-power field was markedly increased in inflamed KA when compared to the other groups. Using similar methods on frozen sections, the expression of HLA-DR was identified on keratinocytes in KA in areas of inflammation but not in other lesions under study. We hypothesize that increased numbers of LCs in inflamed KA are part of the process which results in tumor regression.

Original languageEnglish
Pages (from-to)104-108
Number of pages5
JournalJournal of Cutaneous Pathology
Volume15
Issue number2
StatePublished - Jan 1 1988

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Keratoacanthoma
S100 Proteins
Squamous Cell Carcinoma
Langerhans Cells
Frozen Sections
HLA-DR Antigens
Keratinocytes
Inflammation
Neoplasms

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine

Cite this

Quantitation of S100 protein-positive cells in inflamed and non-inflamed keratoacanthoma and squamous cell carcinoma. / Korenberg, R.; Penneys, N. S.; Kowalczyk, A.; Nadji, Mehrdad.

In: Journal of Cutaneous Pathology, Vol. 15, No. 2, 01.01.1988, p. 104-108.

Research output: Contribution to journalArticle

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