Quantitation of platelet loss with indium-111 labeled platelets in a hollow-fiber membrane oxygenator and arterial filter during extracorporeal circulation in a pig model

G. M. Palatianos, M. K. Dewanjee, R. P. Robinson, S. Novak, P. K. Dewa njee, M. Kapadvanjwala, L. C. Hsu, G. N. Sfakianakis, G. A. Kaiser

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Abstract

Platelet consumption in a hollow-fiber membrane oxygenator (HFMO) and arterial filter (AF) during cardiopulmonary bypass (CPB) was quantified in five pigs using Indium 111 labeled autologous platelets. Platelet labeling was performed 20-24 hours before CPB. After general endotracheal anesthesia, the pigs were systemically heparinized and were placed on CPB via a median sternotomy. After 3 hours of CPB, radioactivity was quantified with a gamma camera and an ionization chamber. The percent of injected dose (mean ± SD) was 0.79 ± 0.45 in the HFMO, 2.52 ± 0.93 in AF, 4.3 ± 1.2 in blood loss during CPB. Platelet consumption in HFMO during CPB was lower than in blubble oxygenators (19%) or silicone membrane oxygenators (12%) as observed in previous studies.

Original languageEnglish (US)
Pages (from-to)667-670
Number of pages4
JournalASAIO Transactions
Volume35
Issue number3
StatePublished - Jul 1 1989

ASJC Scopus subject areas

  • Biophysics

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    Palatianos, G. M., Dewanjee, M. K., Robinson, R. P., Novak, S., Dewa njee, P. K., Kapadvanjwala, M., Hsu, L. C., Sfakianakis, G. N., & Kaiser, G. A. (1989). Quantitation of platelet loss with indium-111 labeled platelets in a hollow-fiber membrane oxygenator and arterial filter during extracorporeal circulation in a pig model. ASAIO Transactions, 35(3), 667-670.