Quantitation of metabolic change in serial FDG-PET brain scans of pediatric patients with traumatic brain injury

M. F. Georgiou, R. A. Kuker, J. Kuluz, G. N. Sfakianakis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The aim of this research was to develop a method to quantitate the changes in regional brain metabolism on serial FDG-PET scans in children with Traumatic Brain Injury (TBI) in order to determine their response to treatment with psycho stimulant medication. Methods: A Fusion-Based Image Subtraction (FBIS) technique was developed in order to calculate the differences in metabolism between baseline and follow-up scans. The FDG-PET brain images were count normalized to account for differences in the injected activity. Image registration was then performed using a 3D normalized mutual information algorithm and subsequently the fused images were subtracted on a pixel by pixel basis. FBIS extracted areas of increased or decreased metabolism were then compared to a database of normal subjects using NeuroQ (Syntermed, Inc.) and analyzed for statistical significance in cluster areas defined by a standard brain template. Results: Validation of the technique was performed using images from 15 pediatric cases with severe TBI who had baseline (pre-treatment) and follow-up (post-treatment) scans. The FBIS technique was found to be accurate in detecting and localizing the statistically significant changes in regional cerebral metabolism and provided useful data that could be applied clinically. Conclusions: The developed FBIS method identified and quantified areas of regional brain metabolic change thus providing a way to evaluate the effects of pharmacologic treatment in children with TBI. This quantitative technique could be used as an adjunct tool to enhance the interpretation of FDG-PET brain images and aid the referring clinician to assess the response to pharmacologic treatment.

Original languageEnglish (US)
Title of host publication25th Southern Biomedical Engineering Conference 2009
Pages61-62
Number of pages2
DOIs
StatePublished - Nov 6 2009
Event25th Southern Biomedical Engineering Conference 2009 - Miami, FL, United States
Duration: May 15 2009May 17 2009

Publication series

NameIFMBE Proceedings
Volume24
ISSN (Print)1680-0737

Other

Other25th Southern Biomedical Engineering Conference 2009
CountryUnited States
CityMiami, FL
Period5/15/095/17/09

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Keywords

  • Brain
  • FBIS
  • PET
  • TBI

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

Cite this

Georgiou, M. F., Kuker, R. A., Kuluz, J., & Sfakianakis, G. N. (2009). Quantitation of metabolic change in serial FDG-PET brain scans of pediatric patients with traumatic brain injury. In 25th Southern Biomedical Engineering Conference 2009 (pp. 61-62). (IFMBE Proceedings; Vol. 24). https://doi.org/10.1007/978-3-642-01697-4_22