Quantitation of ischemic events after severe traumatic brain injury in humans

A simple scoring system

Anna Teresa Mazzeo, Niki K. Kunene, Sung Choi, Charlotte Gilman, Ross Bullock

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

BACKGROUND: Cerebral ischemia is recognized as one of the most important mechanisms responsible for secondary brain damage following severe traumatic brain injury (TBI), contributing to an increased mortality and a worse neurologic outcome. METHOD: A simple 5-item scoring system, taking into account the occurrence of specific potentially brain-damaging events (hypoxemia, hypotension, low cerebral blood flow, herniation, and low cerebral perfusion pressure) has been tested in a large population of severe TBI patients. Aims of this retrospective study were to validate the ability of the proposed ischemic score to predict neurologic outcome and to correlate the ischemic score with the results of microdialysis-based neurochemical monitoring and brain tissue oxygen monitoring. FINDINGS: In a population of 172 severe TBI patients, a significant correlation was found between ischemic score and neurologic outcome, both at 3 months (r=-0.32; P<0.01) and at 6 months (r=-0.31; P<0.01). Significant correlations were also found with the most important neurochemical analytes. CONCLUSIONS: The ischemic score proposed here, may be determined during the acute intensive care unit period, and correlates closely with outcome, which can only be determined 3 to 6 months, after injury. It also shows a correlation with neurochemical analytes.

Original languageEnglish
Pages (from-to)170-178
Number of pages9
JournalJournal of Neurosurgical Anesthesiology
Volume18
Issue number3
DOIs
StatePublished - Jul 1 2006
Externally publishedYes

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Cerebrovascular Circulation
Nervous System
Brain
Microdialysis
Brain Ischemia
Hypotension
Population
Intensive Care Units
Retrospective Studies
Oxygen
Mortality
Wounds and Injuries
Traumatic Brain Injury

Keywords

  • Cerebral ischemia
  • Microdialysis
  • Outcome
  • Scoring system
  • Severe head injury

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology

Cite this

Quantitation of ischemic events after severe traumatic brain injury in humans : A simple scoring system. / Mazzeo, Anna Teresa; Kunene, Niki K.; Choi, Sung; Gilman, Charlotte; Bullock, Ross.

In: Journal of Neurosurgical Anesthesiology, Vol. 18, No. 3, 01.07.2006, p. 170-178.

Research output: Contribution to journalArticle

Mazzeo, Anna Teresa ; Kunene, Niki K. ; Choi, Sung ; Gilman, Charlotte ; Bullock, Ross. / Quantitation of ischemic events after severe traumatic brain injury in humans : A simple scoring system. In: Journal of Neurosurgical Anesthesiology. 2006 ; Vol. 18, No. 3. pp. 170-178.
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