Quantitation of in vivo phosphorus metabolites in human brain with magnetic resonance spectroscopic imaging (MRSI)

R. S. Lara; G. B. Matson; J. W. Hugg; A. A. Maudsley; M. W. Weiner

doi:10.1016/0730-725X(93)90033-A

Quantitation of in vivo phosphorus metabolites in human brain with magnetic resonance spectroscopic imaging (MRSI)

R. S. Lara, G. B. Matson, J. W. Hugg, A. A. Maudsley, M. W. Weiner

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

A method for quantitation of in vivo ³¹P metabolite concentrations in human brain with ³¹P magnetic resonance spectroscopic imaging (MRSI) is described. The method relies on comparison of brain and calibration phantom measurements, with corrections for coil loading and metabolite magnetic relaxation. Estimated metabolite concentrations for the centrum semiovale in 11 normal adults (mean ± SD) were: phosphomonoesters = 3.0 ± 0.7 mM, inorganic phosphate = 0.7 ± 0.2 mM, phosphodiesters = 10.9 ± 1.8 mM, phosphocreatine = 2.7 ± 0.5 mM, and adenosine triphosphate = 2.9 ± 0.3 mM. These values are similar to previous results obtained from single-volume localized spectroscopy.

Original language	English (US)
Pages (from-to)	273-278
Number of pages	6
Journal	Magnetic Resonance Imaging
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/0730-725X(93)90033-A
State	Published - 1993
Externally published	Yes

Keywords

Brain phosphorus in vivo
Spectral quantitation
Spectroscopic imaging

ASJC Scopus subject areas

Biophysics
Clinical Biochemistry
Structural Biology
Radiology Nuclear Medicine and imaging
Condensed Matter Physics

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10.1016/0730-725X(93)90033-A

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title = "Quantitation of in vivo phosphorus metabolites in human brain with magnetic resonance spectroscopic imaging (MRSI)",

abstract = "A method for quantitation of in vivo 31P metabolite concentrations in human brain with 31P magnetic resonance spectroscopic imaging (MRSI) is described. The method relies on comparison of brain and calibration phantom measurements, with corrections for coil loading and metabolite magnetic relaxation. Estimated metabolite concentrations for the centrum semiovale in 11 normal adults (mean ± SD) were: phosphomonoesters = 3.0 ± 0.7 mM, inorganic phosphate = 0.7 ± 0.2 mM, phosphodiesters = 10.9 ± 1.8 mM, phosphocreatine = 2.7 ± 0.5 mM, and adenosine triphosphate = 2.9 ± 0.3 mM. These values are similar to previous results obtained from single-volume localized spectroscopy.",

keywords = "Brain phosphorus in vivo, Spectral quantitation, Spectroscopic imaging",

author = "Lara, {R. S.} and Matson, {G. B.} and Hugg, {J. W.} and Maudsley, {A. A.} and Weiner, {M. W.}",

year = "1993",

doi = "10.1016/0730-725X(93)90033-A",

language = "English (US)",

volume = "11",

pages = "273--278",

journal = "Magnetic Resonance Imaging",

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T1 - Quantitation of in vivo phosphorus metabolites in human brain with magnetic resonance spectroscopic imaging (MRSI)

AU - Lara, R. S.

AU - Matson, G. B.

AU - Hugg, J. W.

AU - Maudsley, A. A.

AU - Weiner, M. W.

PY - 1993

Y1 - 1993

N2 - A method for quantitation of in vivo 31P metabolite concentrations in human brain with 31P magnetic resonance spectroscopic imaging (MRSI) is described. The method relies on comparison of brain and calibration phantom measurements, with corrections for coil loading and metabolite magnetic relaxation. Estimated metabolite concentrations for the centrum semiovale in 11 normal adults (mean ± SD) were: phosphomonoesters = 3.0 ± 0.7 mM, inorganic phosphate = 0.7 ± 0.2 mM, phosphodiesters = 10.9 ± 1.8 mM, phosphocreatine = 2.7 ± 0.5 mM, and adenosine triphosphate = 2.9 ± 0.3 mM. These values are similar to previous results obtained from single-volume localized spectroscopy.

AB - A method for quantitation of in vivo 31P metabolite concentrations in human brain with 31P magnetic resonance spectroscopic imaging (MRSI) is described. The method relies on comparison of brain and calibration phantom measurements, with corrections for coil loading and metabolite magnetic relaxation. Estimated metabolite concentrations for the centrum semiovale in 11 normal adults (mean ± SD) were: phosphomonoesters = 3.0 ± 0.7 mM, inorganic phosphate = 0.7 ± 0.2 mM, phosphodiesters = 10.9 ± 1.8 mM, phosphocreatine = 2.7 ± 0.5 mM, and adenosine triphosphate = 2.9 ± 0.3 mM. These values are similar to previous results obtained from single-volume localized spectroscopy.

KW - Brain phosphorus in vivo

KW - Spectral quantitation

KW - Spectroscopic imaging

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JF - Magnetic Resonance Imaging

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Quantitation of in vivo phosphorus metabolites in human brain with magnetic resonance spectroscopic imaging (MRSI)

Abstract

Keywords

ASJC Scopus subject areas

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