Quantitation of in vivo phosphorus metabolites in human brain with magnetic resonance spectroscopic imaging (MRSI)

R. S. Lara, G. B. Matson, J. W. Hugg, Andrew A Maudsley, M. W. Weiner

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A method for quantitation of in vivo 31P metabolite concentrations in human brain with 31P magnetic resonance spectroscopic imaging (MRSI) is described. The method relies on comparison of brain and calibration phantom measurements, with corrections for coil loading and metabolite magnetic relaxation. Estimated metabolite concentrations for the centrum semiovale in 11 normal adults (mean ± SD) were: phosphomonoesters = 3.0 ± 0.7 mM, inorganic phosphate = 0.7 ± 0.2 mM, phosphodiesters = 10.9 ± 1.8 mM, phosphocreatine = 2.7 ± 0.5 mM, and adenosine triphosphate = 2.9 ± 0.3 mM. These values are similar to previous results obtained from single-volume localized spectroscopy.

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalMagnetic Resonance Imaging
Volume11
Issue number2
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

Fingerprint

metabolites
Magnetic resonance
Metabolites
Phosphorus
brain
magnetic resonance
phosphorus
Brain
Magnetic Resonance Imaging
Imaging techniques
Phosphocreatine
Calibration
Magnetic relaxation
Spectrum Analysis
adenosine triphosphate
Adenosine Triphosphate
Phosphates
magnetic relaxation
phosphates
coils

Keywords

  • Brain phosphorus in vivo
  • Spectral quantitation
  • Spectroscopic imaging

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Quantitation of in vivo phosphorus metabolites in human brain with magnetic resonance spectroscopic imaging (MRSI). / Lara, R. S.; Matson, G. B.; Hugg, J. W.; Maudsley, Andrew A; Weiner, M. W.

In: Magnetic Resonance Imaging, Vol. 11, No. 2, 01.01.1993, p. 273-278.

Research output: Contribution to journalArticle

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