Abstract
A method for quantitation of in vivo 31P metabolite concentrations in human brain with 31P magnetic resonance spectroscopic imaging (MRSI) is described. The method relies on comparison of brain and calibration phantom measurements, with corrections for coil loading and metabolite magnetic relaxation. Estimated metabolite concentrations for the centrum semiovale in 11 normal adults (mean ± SD) were: phosphomonoesters = 3.0 ± 0.7 mM, inorganic phosphate = 0.7 ± 0.2 mM, phosphodiesters = 10.9 ± 1.8 mM, phosphocreatine = 2.7 ± 0.5 mM, and adenosine triphosphate = 2.9 ± 0.3 mM. These values are similar to previous results obtained from single-volume localized spectroscopy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 273-278 |
| Number of pages | 6 |
| Journal | Magnetic Resonance Imaging |
| Volume | 11 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1993 |
| Externally published | Yes |
Keywords
- Brain phosphorus in vivo
- Spectral quantitation
- Spectroscopic imaging
ASJC Scopus subject areas
- Biophysics
- Clinical Biochemistry
- Structural Biology
- Radiology Nuclear Medicine and imaging
- Condensed Matter Physics
Fingerprint Dive into the research topics of 'Quantitation of in vivo phosphorus metabolites in human brain with magnetic resonance spectroscopic imaging (MRSI)'. Together they form a unique fingerprint.
Cite this
Lara, R. S., Matson, G. B., Hugg, J. W., Maudsley, A. A., & Weiner, M. W. (1993). Quantitation of in vivo phosphorus metabolites in human brain with magnetic resonance spectroscopic imaging (MRSI). Magnetic Resonance Imaging, 11(2), 273-278. https://doi.org/10.1016/0730-725X(93)90033-A