Abstract
A method for quantitation of in vivo 31P metabolite concentrations in human brain with 31P magnetic resonance spectroscopic imaging (MRSI) is described. The method relies on comparison of brain and calibration phantom measurements, with corrections for coil loading and metabolite magnetic relaxation. Estimated metabolite concentrations for the centrum semiovale in 11 normal adults (mean ± SD) were: phosphomonoesters = 3.0 ± 0.7 mM, inorganic phosphate = 0.7 ± 0.2 mM, phosphodiesters = 10.9 ± 1.8 mM, phosphocreatine = 2.7 ± 0.5 mM, and adenosine triphosphate = 2.9 ± 0.3 mM. These values are similar to previous results obtained from single-volume localized spectroscopy.
| Original language | English |
|---|---|
| Pages (from-to) | 273-278 |
| Number of pages | 6 |
| Journal | Magnetic Resonance Imaging |
| Volume | 11 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1993 |
| Externally published | Yes |
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Keywords
- Brain phosphorus in vivo
- Spectral quantitation
- Spectroscopic imaging
ASJC Scopus subject areas
- Biophysics
- Clinical Biochemistry
- Structural Biology
- Radiology Nuclear Medicine and imaging
- Condensed Matter Physics
Cite this
Quantitation of in vivo phosphorus metabolites in human brain with magnetic resonance spectroscopic imaging (MRSI). / Lara, R. S.; Matson, G. B.; Hugg, J. W.; Maudsley, Andrew A; Weiner, M. W.
In: Magnetic Resonance Imaging, Vol. 11, No. 2, 01.01.1993, p. 273-278.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Quantitation of in vivo phosphorus metabolites in human brain with magnetic resonance spectroscopic imaging (MRSI)
AU - Lara, R. S.
AU - Matson, G. B.
AU - Hugg, J. W.
AU - Maudsley, Andrew A
AU - Weiner, M. W.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - A method for quantitation of in vivo 31P metabolite concentrations in human brain with 31P magnetic resonance spectroscopic imaging (MRSI) is described. The method relies on comparison of brain and calibration phantom measurements, with corrections for coil loading and metabolite magnetic relaxation. Estimated metabolite concentrations for the centrum semiovale in 11 normal adults (mean ± SD) were: phosphomonoesters = 3.0 ± 0.7 mM, inorganic phosphate = 0.7 ± 0.2 mM, phosphodiesters = 10.9 ± 1.8 mM, phosphocreatine = 2.7 ± 0.5 mM, and adenosine triphosphate = 2.9 ± 0.3 mM. These values are similar to previous results obtained from single-volume localized spectroscopy.
AB - A method for quantitation of in vivo 31P metabolite concentrations in human brain with 31P magnetic resonance spectroscopic imaging (MRSI) is described. The method relies on comparison of brain and calibration phantom measurements, with corrections for coil loading and metabolite magnetic relaxation. Estimated metabolite concentrations for the centrum semiovale in 11 normal adults (mean ± SD) were: phosphomonoesters = 3.0 ± 0.7 mM, inorganic phosphate = 0.7 ± 0.2 mM, phosphodiesters = 10.9 ± 1.8 mM, phosphocreatine = 2.7 ± 0.5 mM, and adenosine triphosphate = 2.9 ± 0.3 mM. These values are similar to previous results obtained from single-volume localized spectroscopy.
KW - Brain phosphorus in vivo
KW - Spectral quantitation
KW - Spectroscopic imaging
UR - http://www.scopus.com/inward/record.url?scp=0027213418&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027213418&partnerID=8YFLogxK
U2 - 10.1016/0730-725X(93)90033-A
DO - 10.1016/0730-725X(93)90033-A
M3 - Article
C2 - 8455438
AN - SCOPUS:0027213418
VL - 11
SP - 273
EP - 278
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
SN - 0730-725X
IS - 2
ER -