Quantitation of in vivo phosphorus metabolites in human brain with magnetic resonance spectroscopic imaging (MRSI)

R. S. Lara, G. B. Matson, J. W. Hugg, A. A. Maudsley, M. W. Weiner

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

A method for quantitation of in vivo 31P metabolite concentrations in human brain with 31P magnetic resonance spectroscopic imaging (MRSI) is described. The method relies on comparison of brain and calibration phantom measurements, with corrections for coil loading and metabolite magnetic relaxation. Estimated metabolite concentrations for the centrum semiovale in 11 normal adults (mean ± SD) were: phosphomonoesters = 3.0 ± 0.7 mM, inorganic phosphate = 0.7 ± 0.2 mM, phosphodiesters = 10.9 ± 1.8 mM, phosphocreatine = 2.7 ± 0.5 mM, and adenosine triphosphate = 2.9 ± 0.3 mM. These values are similar to previous results obtained from single-volume localized spectroscopy.

Original languageEnglish (US)
Pages (from-to)273-278
Number of pages6
JournalMagnetic Resonance Imaging
Volume11
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

Keywords

  • Brain phosphorus in vivo
  • Spectral quantitation
  • Spectroscopic imaging

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

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