Quantitation of Acute Phase Proteins and Protein Electrophoresis Fractions in Ferrets

Michelle Ravich, Cathy Johnson-Delaney, Susan Kelleher, Laurie Hess, Kristopher Arheart, Carolyn Cray

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The objective of this study was to evaluate the application of acute phase protein assays for C-reactive protein, haptoglobin, and serum amyloid A, as well as protein electrophoresis, in ferrets. Samples from 41 clinically normal and 52 clinically abnormal pet ferrets were submitted from veterinary clinics within the United States. Reference intervals were calculated for all analytes from the clinically normal group using the robust method. The clinically abnormal group demonstrated significant elevations in the concentrations of the following analytes (. P < 0.05): total protein, alpha 2 globulins, beta globulins, gamma globulins, serum amyloid A, and haptoglobin. The preliminary results of this research investigation support a potential role for these acute phase protein assays to be used as adjunct tests for monitoring inflammation and disease in ferrets.

Original languageEnglish (US)
Pages (from-to)201-208
Number of pages8
JournalJournal of Exotic Pet Medicine
Volume24
Issue number2
DOIs
StatePublished - Apr 1 2015

Fingerprint

Ferrets
acute phase proteins
Acute-Phase Proteins
ferrets
electrophoresis
Electrophoresis
Serum Amyloid A Protein
Haptoglobins
haptoglobins
amyloid
Beta-Globulins
Alpha-Globulins
Animal Hospitals
gamma-globulins
Proteins
proteins
gamma-Globulins
Pets
C-reactive protein
veterinary clinics

Keywords

  • Acute phase protein
  • C-reactive protein
  • Ferret
  • Haptoglobin
  • Protein electrophoresis
  • Serum amyloid A

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Quantitation of Acute Phase Proteins and Protein Electrophoresis Fractions in Ferrets. / Ravich, Michelle; Johnson-Delaney, Cathy; Kelleher, Susan; Hess, Laurie; Arheart, Kristopher; Cray, Carolyn.

In: Journal of Exotic Pet Medicine, Vol. 24, No. 2, 01.04.2015, p. 201-208.

Research output: Contribution to journalArticle

Ravich, Michelle ; Johnson-Delaney, Cathy ; Kelleher, Susan ; Hess, Laurie ; Arheart, Kristopher ; Cray, Carolyn. / Quantitation of Acute Phase Proteins and Protein Electrophoresis Fractions in Ferrets. In: Journal of Exotic Pet Medicine. 2015 ; Vol. 24, No. 2. pp. 201-208.
@article{e8ed5e993d544d8f8f08b249fe3e8959,
title = "Quantitation of Acute Phase Proteins and Protein Electrophoresis Fractions in Ferrets",
abstract = "The objective of this study was to evaluate the application of acute phase protein assays for C-reactive protein, haptoglobin, and serum amyloid A, as well as protein electrophoresis, in ferrets. Samples from 41 clinically normal and 52 clinically abnormal pet ferrets were submitted from veterinary clinics within the United States. Reference intervals were calculated for all analytes from the clinically normal group using the robust method. The clinically abnormal group demonstrated significant elevations in the concentrations of the following analytes (. P < 0.05): total protein, alpha 2 globulins, beta globulins, gamma globulins, serum amyloid A, and haptoglobin. The preliminary results of this research investigation support a potential role for these acute phase protein assays to be used as adjunct tests for monitoring inflammation and disease in ferrets.",
keywords = "Acute phase protein, C-reactive protein, Ferret, Haptoglobin, Protein electrophoresis, Serum amyloid A",
author = "Michelle Ravich and Cathy Johnson-Delaney and Susan Kelleher and Laurie Hess and Kristopher Arheart and Carolyn Cray",
year = "2015",
month = "4",
day = "1",
doi = "10.1053/j.jepm.2015.04.010",
language = "English (US)",
volume = "24",
pages = "201--208",
journal = "Journal of Exotic Pet Medicine",
issn = "1557-5063",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - Quantitation of Acute Phase Proteins and Protein Electrophoresis Fractions in Ferrets

AU - Ravich, Michelle

AU - Johnson-Delaney, Cathy

AU - Kelleher, Susan

AU - Hess, Laurie

AU - Arheart, Kristopher

AU - Cray, Carolyn

PY - 2015/4/1

Y1 - 2015/4/1

N2 - The objective of this study was to evaluate the application of acute phase protein assays for C-reactive protein, haptoglobin, and serum amyloid A, as well as protein electrophoresis, in ferrets. Samples from 41 clinically normal and 52 clinically abnormal pet ferrets were submitted from veterinary clinics within the United States. Reference intervals were calculated for all analytes from the clinically normal group using the robust method. The clinically abnormal group demonstrated significant elevations in the concentrations of the following analytes (. P < 0.05): total protein, alpha 2 globulins, beta globulins, gamma globulins, serum amyloid A, and haptoglobin. The preliminary results of this research investigation support a potential role for these acute phase protein assays to be used as adjunct tests for monitoring inflammation and disease in ferrets.

AB - The objective of this study was to evaluate the application of acute phase protein assays for C-reactive protein, haptoglobin, and serum amyloid A, as well as protein electrophoresis, in ferrets. Samples from 41 clinically normal and 52 clinically abnormal pet ferrets were submitted from veterinary clinics within the United States. Reference intervals were calculated for all analytes from the clinically normal group using the robust method. The clinically abnormal group demonstrated significant elevations in the concentrations of the following analytes (. P < 0.05): total protein, alpha 2 globulins, beta globulins, gamma globulins, serum amyloid A, and haptoglobin. The preliminary results of this research investigation support a potential role for these acute phase protein assays to be used as adjunct tests for monitoring inflammation and disease in ferrets.

KW - Acute phase protein

KW - C-reactive protein

KW - Ferret

KW - Haptoglobin

KW - Protein electrophoresis

KW - Serum amyloid A

UR - http://www.scopus.com/inward/record.url?scp=84930764966&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930764966&partnerID=8YFLogxK

U2 - 10.1053/j.jepm.2015.04.010

DO - 10.1053/j.jepm.2015.04.010

M3 - Article

AN - SCOPUS:84930764966

VL - 24

SP - 201

EP - 208

JO - Journal of Exotic Pet Medicine

JF - Journal of Exotic Pet Medicine

SN - 1557-5063

IS - 2

ER -