Quantifying the effect of posture on intracranial physiology in humans by MRI flow studies

Noam Alperin, Sang H. Lee, Anusha Sivaramakrishnan, Stephen G. Hushek

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Purpose: To quantify the effect of posture on intracranial physiology In humans by MRI, and demonstrate the relationship between intracranial compliance (ICC) and pressure (ICP), and the pulsatility of blood and CSF flows. Materials and Methods: Ten healthy volunteers (29 ± 7 years old) were scanned in the supine and sitting positions using a vertical gap MRI scanner. Pulsatile blood and CSF flows into and out from the brain were visualized and quantified using time-of-flight (TOF) and cine phase-contrast techniques, respectively. The total cerebral blood flow (tCBF), venous outflow, ICC, and ICP for the two postures were then calculated from the arterial, venous, and CSF volumetric flow rate waveforms using a previously described method. Results: In the upright posture, venous outflow is considerably less pulsatile (57%) and occurs predominantly through the vertebral plexus, while in the supine posture venous outflow occurs predominantly through the internal jugular veins. A slightly lower tCBF (12%), a considerably smaller CSF volume oscillating between the cranium and the spinal canal (48%), and a much larger ICC (2.8-fold) with a corresponding decrease in the MRI-derlved ICP values were measured in the sitting position. Conclusion: The effect of posture on intracranial physiology can be quantified by MRI because posture-related changes in ICC and ICP strongly affect the dynamics of cerebral blood and CSF flows. This study provides important insight into the coupling that exists between arterial, venous, and CSF flow dynamics, and how it is affected by posture.

Original languageEnglish
Pages (from-to)591-596
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Volume22
Issue number5
DOIs
StatePublished - Nov 1 2005
Externally publishedYes

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Posture
Cerebrovascular Circulation
Compliance
Pressure
Spinal Canal
Supine Position
Jugular Veins
Intracranial Pressure
Skull
Healthy Volunteers
Brain

Keywords

  • CBF
  • Cerebral venous outflow
  • Cine phase contrast
  • CSF flow
  • Intracranial compliance and pressure
  • Upright posture

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Quantifying the effect of posture on intracranial physiology in humans by MRI flow studies. / Alperin, Noam; Lee, Sang H.; Sivaramakrishnan, Anusha; Hushek, Stephen G.

In: Journal of Magnetic Resonance Imaging, Vol. 22, No. 5, 01.11.2005, p. 591-596.

Research output: Contribution to journalArticle

Alperin, Noam ; Lee, Sang H. ; Sivaramakrishnan, Anusha ; Hushek, Stephen G. / Quantifying the effect of posture on intracranial physiology in humans by MRI flow studies. In: Journal of Magnetic Resonance Imaging. 2005 ; Vol. 22, No. 5. pp. 591-596.
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