Quantification of the ciliary muscle and crystalline lens interaction during accommodation with synchronous OCT imaging

Marco Ruggeri, Carolina de Freitas, Siobhan Williams, Victor M. Hernandez, Florence Cabot, Nilufer Yesilirmak, Karam Alawa, Yu Cherng Chang, Sonia H Yoo, Giovanni Gregori, Jean-Marie A Parel, Fabrice Manns

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Two SD-OCT systems and a dual channel accommodation target were combined and precisely synchronized to simultaneously image the anterior segment and the ciliary muscle during dynamic accommodation. The imaging system simultaneously generates two synchronized OCT image sequences of the anterior segment and ciliary muscle with an imaging speed of 13 frames per second. The system was used to acquire OCT image sequences of a non-presbyopic and a pre-presbyopic subject accommodating in response to step changes in vergence. The image sequences were processed to extract dynamic morphological data from the crystalline lens and the ciliary muscle. The synchronization between the OCT systems allowed the precise correlation of anatomical changes occurring in the crystalline lens and ciliary muscle at identical time points during accommodation. To describe the dynamic interaction between the crystalline lens and ciliary muscle, we introduce accommodation state diagrams that display the relation between anatomical changes occurring in the accommodating crystalline lens and ciliary muscle.

Original languageEnglish (US)
Pages (from-to)1351-1364
Number of pages14
JournalBiomedical Optics Express
Volume7
Issue number4
DOIs
StatePublished - Mar 17 2016

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

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