Quantification of Longitudinal Changes in Retinal Vasculature from Wide-Field Fluorescein Angiography via a Novel Registration and Change Detection Approach

Li Ding, Ajay Kuriyan, Rajeev Ramchandran, Gaurav Sharma

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Wide-field fluorescein angiography (FA) images are commonly used in ophthalmology to assess longitudinal changes in retinal vasculature, specifically, non-perfusion. Current practice relies on manual qualitative comparisons between images taken at successive clinic visits, a few months apart. Objective quantitative assessments, although desirable for evaluating disease progression and treatment, are impractical to perform manually and challenging for image analysis because of the changes in the capture viewpoints and temporal imaging variations seen as the FA dye injection perfuses the retina. We propose a methodology for quantifying retinal non-perfusion by automated analysis of the FA images captured during successive clinical visits. Blood vessels are first detected in the image from each visit. The vascular networks in FA images are then precisely registered to obtain a co-aligned pair via parametric chamfer matching under polynomial transformation, a process that explicitly allows for increase or decrease in perfusion. Changes in perfusion are then quantified by identifying the common and distinct regions in co-aligned image pairs. The proposed framework is tested on FA images that are manually annotated by an ophthalmologist to provide ground truth binary vessel masks and to identify vasculature changes. Results indicate that the proposed method provides assessments of vasculature changes that are in good agreement with the ophthalmologist-provided annotations.

Original languageEnglish (US)
Title of host publication2018 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2018 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1070-1074
Number of pages5
Volume2018-April
ISBN (Print)9781538646588
DOIs
StatePublished - Sep 10 2018
Externally publishedYes
Event2018 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2018 - Calgary, Canada
Duration: Apr 15 2018Apr 20 2018

Other

Other2018 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2018
CountryCanada
CityCalgary
Period4/15/184/20/18

Fingerprint

Angiography
Ophthalmology
Blood vessels
Image analysis
Masks
Dyes
Polynomials
Imaging techniques

Keywords

  • Expectation maximization (EM)
  • Image registration
  • Vessel detection
  • Wide-field fluorescein angiography

ASJC Scopus subject areas

  • Software
  • Signal Processing
  • Electrical and Electronic Engineering

Cite this

Ding, L., Kuriyan, A., Ramchandran, R., & Sharma, G. (2018). Quantification of Longitudinal Changes in Retinal Vasculature from Wide-Field Fluorescein Angiography via a Novel Registration and Change Detection Approach. In 2018 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2018 - Proceedings (Vol. 2018-April, pp. 1070-1074). [8461363] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ICASSP.2018.8461363

Quantification of Longitudinal Changes in Retinal Vasculature from Wide-Field Fluorescein Angiography via a Novel Registration and Change Detection Approach. / Ding, Li; Kuriyan, Ajay; Ramchandran, Rajeev; Sharma, Gaurav.

2018 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2018 - Proceedings. Vol. 2018-April Institute of Electrical and Electronics Engineers Inc., 2018. p. 1070-1074 8461363.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ding, L, Kuriyan, A, Ramchandran, R & Sharma, G 2018, Quantification of Longitudinal Changes in Retinal Vasculature from Wide-Field Fluorescein Angiography via a Novel Registration and Change Detection Approach. in 2018 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2018 - Proceedings. vol. 2018-April, 8461363, Institute of Electrical and Electronics Engineers Inc., pp. 1070-1074, 2018 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2018, Calgary, Canada, 4/15/18. https://doi.org/10.1109/ICASSP.2018.8461363
Ding L, Kuriyan A, Ramchandran R, Sharma G. Quantification of Longitudinal Changes in Retinal Vasculature from Wide-Field Fluorescein Angiography via a Novel Registration and Change Detection Approach. In 2018 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2018 - Proceedings. Vol. 2018-April. Institute of Electrical and Electronics Engineers Inc. 2018. p. 1070-1074. 8461363 https://doi.org/10.1109/ICASSP.2018.8461363
Ding, Li ; Kuriyan, Ajay ; Ramchandran, Rajeev ; Sharma, Gaurav. / Quantification of Longitudinal Changes in Retinal Vasculature from Wide-Field Fluorescein Angiography via a Novel Registration and Change Detection Approach. 2018 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2018 - Proceedings. Vol. 2018-April Institute of Electrical and Electronics Engineers Inc., 2018. pp. 1070-1074
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