Abstract
Purpose: To determine quality of life (QOL) after hyperfractionated radiation and chemotherapy. Materials and Methods: Functional Assessment of Cancer Therapy (FACT) and the Functional Assessment of Cancer Therapy-Head and Neck (FACT H-N) questionnaires were administered to protocol patients at baseline study entry, during and at the completion of therapy, and during subsequent follow-up. Results: Twenty-four patients completed baseline QOL questionnaires. Six subsequent assessments were given to patients who were available for follow-up. Social/family well-being and relationship with doctor subscores were not significantly different from baseline. Emotional well-being was not different from baseline initially, but actually showed a significant increase 6 months after completion of radiation, seen on assessments 5 and 6 (P < 0.01). Physical and functional well-being subscores, total FACT-G score, head and neck subscores, and total FACT H-N score all showed initial decreases during, at the completion of radiation, or, in some subscores, up to 3 months postradiation. However, all these scores recovered to baseline levels. These scores subsequently showed a significant increase after 6 months to 1 year in all but the physical well-being and head and neck subscores, which remained at baseline. Conclusion: QOL scores returned to baseline levels or increased at 6 to 12 months postradiation in long-term survivors who completed QOL questionnaires.
| Original language | English |
|---|---|
| Pages (from-to) | 359-366 |
| Number of pages | 8 |
| Journal | American Journal of Clinical Oncology: Cancer Clinical Trials |
| Volume | 28 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 1 2005 |
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Keywords
- Head and neck cancer
- Hyperfractionated radiation therapy
- Quality of life
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Quality-of-life assessment after hyperfractionated radiation therapy and 5-fluorouracil, cisplatin, and paclitaxel (taxol) in inoperable and/or unresectable head and neck squamous cell carcinoma. / Abdel-Wahab, May; Abitbol, Andre; Lewin, Alan; Troner, Michael; Hamilton, Kara; Markoe, Arnold.
In: American Journal of Clinical Oncology: Cancer Clinical Trials, Vol. 28, No. 4, 01.08.2005, p. 359-366.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Quality-of-life assessment after hyperfractionated radiation therapy and 5-fluorouracil, cisplatin, and paclitaxel (taxol) in inoperable and/or unresectable head and neck squamous cell carcinoma
AU - Abdel-Wahab, May
AU - Abitbol, Andre
AU - Lewin, Alan
AU - Troner, Michael
AU - Hamilton, Kara
AU - Markoe, Arnold
PY - 2005/8/1
Y1 - 2005/8/1
N2 - Purpose: To determine quality of life (QOL) after hyperfractionated radiation and chemotherapy. Materials and Methods: Functional Assessment of Cancer Therapy (FACT) and the Functional Assessment of Cancer Therapy-Head and Neck (FACT H-N) questionnaires were administered to protocol patients at baseline study entry, during and at the completion of therapy, and during subsequent follow-up. Results: Twenty-four patients completed baseline QOL questionnaires. Six subsequent assessments were given to patients who were available for follow-up. Social/family well-being and relationship with doctor subscores were not significantly different from baseline. Emotional well-being was not different from baseline initially, but actually showed a significant increase 6 months after completion of radiation, seen on assessments 5 and 6 (P < 0.01). Physical and functional well-being subscores, total FACT-G score, head and neck subscores, and total FACT H-N score all showed initial decreases during, at the completion of radiation, or, in some subscores, up to 3 months postradiation. However, all these scores recovered to baseline levels. These scores subsequently showed a significant increase after 6 months to 1 year in all but the physical well-being and head and neck subscores, which remained at baseline. Conclusion: QOL scores returned to baseline levels or increased at 6 to 12 months postradiation in long-term survivors who completed QOL questionnaires.
AB - Purpose: To determine quality of life (QOL) after hyperfractionated radiation and chemotherapy. Materials and Methods: Functional Assessment of Cancer Therapy (FACT) and the Functional Assessment of Cancer Therapy-Head and Neck (FACT H-N) questionnaires were administered to protocol patients at baseline study entry, during and at the completion of therapy, and during subsequent follow-up. Results: Twenty-four patients completed baseline QOL questionnaires. Six subsequent assessments were given to patients who were available for follow-up. Social/family well-being and relationship with doctor subscores were not significantly different from baseline. Emotional well-being was not different from baseline initially, but actually showed a significant increase 6 months after completion of radiation, seen on assessments 5 and 6 (P < 0.01). Physical and functional well-being subscores, total FACT-G score, head and neck subscores, and total FACT H-N score all showed initial decreases during, at the completion of radiation, or, in some subscores, up to 3 months postradiation. However, all these scores recovered to baseline levels. These scores subsequently showed a significant increase after 6 months to 1 year in all but the physical well-being and head and neck subscores, which remained at baseline. Conclusion: QOL scores returned to baseline levels or increased at 6 to 12 months postradiation in long-term survivors who completed QOL questionnaires.
KW - Head and neck cancer
KW - Hyperfractionated radiation therapy
KW - Quality of life
UR - http://www.scopus.com/inward/record.url?scp=23244449239&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23244449239&partnerID=8YFLogxK
U2 - 10.1097/01.coc.0000158837.47450.81
DO - 10.1097/01.coc.0000158837.47450.81
M3 - Article
C2 - 16062077
AN - SCOPUS:23244449239
VL - 28
SP - 359
EP - 366
JO - American Journal of Clinical Oncology
JF - American Journal of Clinical Oncology
SN - 0277-3732
IS - 4
ER -