Quality of life among HIV-infected individuals failing first-line antiretroviral therapy in resource-limited settings

Thiago S. Torres, Linda J. Harrison, Alberto M. La Rosa, Jeffrey A. Lavenberg, Lu Zheng, Steven Safren, McNeil Ngongondo, Selvamuthu Poongulali, Mitch Matoga, Wadzanai Samaneka, Ann C. Collier, Michael D. Hughes

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We evaluated health-related quality of life (QoL) in HIV infection participants with virologic failure (VF) on first-line antiretroviral therapy (ART) in 9 resource-limited settings (RLS). ACTG SF-21 was completed by 512 participants at A5273 study entry; 8 domains assessed: general health perceptions (GHP), physical functioning (PF), role functioning (RF), social functioning (SF), cognitive functioning (CF), pain (P), mental health (MH), and energy/fatigue (E/F); each was scored between 0 (worst) to 100 (best). Mean QoL scores ranged from 67 (GHP) to 91 (PF, SF, CF). QoL varied by country; high VL and low CD4 were associated with worse QoL in most domains, except RF (VL only), SF (CD4 only) and CF (neither). Number of comorbidities, BMI and history of AIDS were associated with some domains. Relationships between QoL and VL varied among countries for all domains. The association of worse disease status with worse QoL may reflect low QoL when ART was initiated and/or deterioration associated with VF.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalAIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
DOIs
StateAccepted/In press - Jan 18 2018

    Fingerprint

Keywords

  • antiretroviral therapy
  • Health-related quality of life
  • HIV
  • resource-limited settings
  • virologic failure

ASJC Scopus subject areas

  • Health(social science)
  • Social Psychology
  • Public Health, Environmental and Occupational Health

Cite this

Torres, T. S., Harrison, L. J., La Rosa, A. M., Lavenberg, J. A., Zheng, L., Safren, S., Ngongondo, M., Poongulali, S., Matoga, M., Samaneka, W., Collier, A. C., & Hughes, M. D. (Accepted/In press). Quality of life among HIV-infected individuals failing first-line antiretroviral therapy in resource-limited settings. AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, 1-9. https://doi.org/10.1080/09540121.2018.1427207