Abstract
We evaluated health-related quality of life (QoL) in HIV infection participants with virologic failure (VF) on first-line antiretroviral therapy (ART) in 9 resource-limited settings (RLS). ACTG SF-21 was completed by 512 participants at A5273 study entry; 8 domains assessed: general health perceptions (GHP), physical functioning (PF), role functioning (RF), social functioning (SF), cognitive functioning (CF), pain (P), mental health (MH), and energy/fatigue (E/F); each was scored between 0 (worst) to 100 (best). Mean QoL scores ranged from 67 (GHP) to 91 (PF, SF, CF). QoL varied by country; high VL and low CD4 were associated with worse QoL in most domains, except RF (VL only), SF (CD4 only) and CF (neither). Number of comorbidities, BMI and history of AIDS were associated with some domains. Relationships between QoL and VL varied among countries for all domains. The association of worse disease status with worse QoL may reflect low QoL when ART was initiated and/or deterioration associated with VF.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-9 |
| Number of pages | 9 |
| Journal | AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV |
| DOIs | |
| State | Accepted/In press - Jan 18 2018 |
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Keywords
- antiretroviral therapy
- Health-related quality of life
- HIV
- resource-limited settings
- virologic failure
ASJC Scopus subject areas
- Health(social science)
- Social Psychology
- Public Health, Environmental and Occupational Health
Cite this
Quality of life among HIV-infected individuals failing first-line antiretroviral therapy in resource-limited settings. / Torres, Thiago S.; Harrison, Linda J.; La Rosa, Alberto M.; Lavenberg, Jeffrey A.; Zheng, Lu; Safren, Steven; Ngongondo, McNeil; Poongulali, Selvamuthu; Matoga, Mitch; Samaneka, Wadzanai; Collier, Ann C.; Hughes, Michael D.
In: AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, 18.01.2018, p. 1-9.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Quality of life among HIV-infected individuals failing first-line antiretroviral therapy in resource-limited settings
AU - Torres, Thiago S.
AU - Harrison, Linda J.
AU - La Rosa, Alberto M.
AU - Lavenberg, Jeffrey A.
AU - Zheng, Lu
AU - Safren, Steven
AU - Ngongondo, McNeil
AU - Poongulali, Selvamuthu
AU - Matoga, Mitch
AU - Samaneka, Wadzanai
AU - Collier, Ann C.
AU - Hughes, Michael D.
PY - 2018/1/18
Y1 - 2018/1/18
N2 - We evaluated health-related quality of life (QoL) in HIV infection participants with virologic failure (VF) on first-line antiretroviral therapy (ART) in 9 resource-limited settings (RLS). ACTG SF-21 was completed by 512 participants at A5273 study entry; 8 domains assessed: general health perceptions (GHP), physical functioning (PF), role functioning (RF), social functioning (SF), cognitive functioning (CF), pain (P), mental health (MH), and energy/fatigue (E/F); each was scored between 0 (worst) to 100 (best). Mean QoL scores ranged from 67 (GHP) to 91 (PF, SF, CF). QoL varied by country; high VL and low CD4 were associated with worse QoL in most domains, except RF (VL only), SF (CD4 only) and CF (neither). Number of comorbidities, BMI and history of AIDS were associated with some domains. Relationships between QoL and VL varied among countries for all domains. The association of worse disease status with worse QoL may reflect low QoL when ART was initiated and/or deterioration associated with VF.
AB - We evaluated health-related quality of life (QoL) in HIV infection participants with virologic failure (VF) on first-line antiretroviral therapy (ART) in 9 resource-limited settings (RLS). ACTG SF-21 was completed by 512 participants at A5273 study entry; 8 domains assessed: general health perceptions (GHP), physical functioning (PF), role functioning (RF), social functioning (SF), cognitive functioning (CF), pain (P), mental health (MH), and energy/fatigue (E/F); each was scored between 0 (worst) to 100 (best). Mean QoL scores ranged from 67 (GHP) to 91 (PF, SF, CF). QoL varied by country; high VL and low CD4 were associated with worse QoL in most domains, except RF (VL only), SF (CD4 only) and CF (neither). Number of comorbidities, BMI and history of AIDS were associated with some domains. Relationships between QoL and VL varied among countries for all domains. The association of worse disease status with worse QoL may reflect low QoL when ART was initiated and/or deterioration associated with VF.
KW - antiretroviral therapy
KW - Health-related quality of life
KW - HIV
KW - resource-limited settings
KW - virologic failure
UR - http://www.scopus.com/inward/record.url?scp=85040962548&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85040962548&partnerID=8YFLogxK
U2 - 10.1080/09540121.2018.1427207
DO - 10.1080/09540121.2018.1427207
M3 - Article
C2 - 29343078
AN - SCOPUS:85040962548
SP - 1
EP - 9
JO - AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
JF - AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
SN - 0954-0121
ER -