TY - JOUR
T1 - Quality of life among HIV-infected individuals failing first-line antiretroviral therapy in resource-limited settings
AU - Torres, Thiago S.
AU - Harrison, Linda J.
AU - La Rosa, Alberto M.
AU - Lavenberg, Jeffrey A.
AU - Zheng, Lu
AU - Safren, Steven A.
AU - Ngongondo, McNeil
AU - Poongulali, Selvamuthu
AU - Matoga, Mitch
AU - Samaneka, Wadzanai
AU - Collier, Ann C.
AU - Hughes, Michael D.
N1 - Funding Information:
This work was supported by National Institute of Allergy and Infectious Diseases [grant number 2UM1AI069423,AI069432, AI069438,AI069481,K24DA040489,K24MH094214,U01AI06 8636,UM1 AI068634,UM1 AI069471].
Funding Information:
This work was supported by National Institute of Allergy and Infectious Diseases [grant number 2UM1AI069423,AI069432,AI069438,AI069481,K24DA040489,K24MH094214,U01AI068636,UM1 AI068634,UM1 AI069471].
PY - 2018/8/3
Y1 - 2018/8/3
N2 - We evaluated health-related quality of life (QoL) in HIV infection participants with virologic failure (VF) on first-line antiretroviral therapy (ART) in 9 resource-limited settings (RLS). ACTG SF-21 was completed by 512 participants at A5273 study entry; 8 domains assessed: general health perceptions (GHP), physical functioning (PF), role functioning (RF), social functioning (SF), cognitive functioning (CF), pain (P), mental health (MH), and energy/fatigue (E/F); each was scored between 0 (worst) to 100 (best). Mean QoL scores ranged from 67 (GHP) to 91 (PF, SF, CF). QoL varied by country; high VL and low CD4 were associated with worse QoL in most domains, except RF (VL only), SF (CD4 only) and CF (neither). Number of comorbidities, BMI and history of AIDS were associated with some domains. Relationships between QoL and VL varied among countries for all domains. The association of worse disease status with worse QoL may reflect low QoL when ART was initiated and/or deterioration associated with VF.
AB - We evaluated health-related quality of life (QoL) in HIV infection participants with virologic failure (VF) on first-line antiretroviral therapy (ART) in 9 resource-limited settings (RLS). ACTG SF-21 was completed by 512 participants at A5273 study entry; 8 domains assessed: general health perceptions (GHP), physical functioning (PF), role functioning (RF), social functioning (SF), cognitive functioning (CF), pain (P), mental health (MH), and energy/fatigue (E/F); each was scored between 0 (worst) to 100 (best). Mean QoL scores ranged from 67 (GHP) to 91 (PF, SF, CF). QoL varied by country; high VL and low CD4 were associated with worse QoL in most domains, except RF (VL only), SF (CD4 only) and CF (neither). Number of comorbidities, BMI and history of AIDS were associated with some domains. Relationships between QoL and VL varied among countries for all domains. The association of worse disease status with worse QoL may reflect low QoL when ART was initiated and/or deterioration associated with VF.
KW - HIV
KW - Health-related quality of life
KW - antiretroviral therapy
KW - resource-limited settings
KW - virologic failure
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U2 - 10.1080/09540121.2018.1427207
DO - 10.1080/09540121.2018.1427207
M3 - Article
C2 - 29343078
AN - SCOPUS:85040962548
VL - 30
SP - 954
EP - 962
JO - AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
JF - AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
SN - 0954-0121
IS - 8
ER -