QT prolongation and serum sotalol concentration are highly correlated following intravenous and oral sotalol

John C. Somberg, Richard A. Preston, Vasant Ranade, Janos Molnar

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Objectives: The aim of this study was to evaluate the correlation between QT interval (QT) and serum sotalol concentration following a single low dose of oral and intravenous sotalol. Methods: Fifteen healthy volunteers received 75 mg intravenous sotalol over 2.5 h and 80 mg oral sotalol in a random order. Serum sotalol concentrations and 12-lead electrocardiograms were obtained simultaneously at baseline and 7 times following dosings. Rate-corrected QT (QTc) was calculated by the Bazett, Fridericia and Framingham formulas. Linear regression analysis was performed between sotalol concentrations and QT measurements. Results: Significant QT prolongation was seen at very low sotalol doses and serum concentrations. QTc intervals calculated by the Framingham and Fridericia formulas showed the strongest and virtually identical correlations with serum sotalol concentration (r ≥ 0.97, p < 0.001) following oral and intravenous administrations. The equation QTc = 0.0342 (sotalol concentration) + 398 closely predicted actual QTc at any sotalol concentration. Conclusions: A strong correlation was observed between serum sotalol concentration and QTc prolongation across the entire concentration range. Low-dose sotalol caused significant QT prolongation. At similar concentrations, intravenous and oral sotalol caused similar QT and QTc effects. Knowing the QT effect can be used to guide further dose increase.

Original languageEnglish (US)
Pages (from-to)219-225
Number of pages7
JournalCardiology
Volume116
Issue number3
DOIs
StatePublished - Aug 1 2010

Keywords

  • Pharmacodynamics
  • QT prolongation
  • Sotalol
  • Torsade de pointes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'QT prolongation and serum sotalol concentration are highly correlated following intravenous and oral sotalol'. Together they form a unique fingerprint.

  • Cite this