Qinghaosu, dietary vitamin E, selenium, and cod-liver oil: Effect on the susceptibility of mice to the malarial parasite Plasmodium yoelii

O. A. Levander, A. L. Ager, V. C. Morris, R. G. May

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Young female mice were fed torula-yeast-based diets deficient in vitamin E or selenium or supplemented with cod-liver oil to determine the effect of host antioxidant status on the therapeutic efficacy of the Chinese traditional antimalarial drug qinghasosu (QHS), a sesquiterpene endoperoxide. Vitamin E deficiency enhanced the antimalarial action of QHS against Plasmodium yoelii, both in terms of decreased parasitemia and improved survival but Se deficiency did not. A vitamin E-deficient diet containing 5% cod-liver oil had such strong antimalarial activity in itself that no additional therapeutic benefit of QHS could be demonstrated. Hematocrit values in parasitized mice treated with QHS or fed the cod-liver-oil-supplemented, vitamin E-deficient diet were normal. Nutritional manipulation of host antioxidant status may prove a promising prophylactic and/or therapeutic tool for the control of malaria.

Original languageEnglish (US)
Pages (from-to)346-352
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume50
Issue number2
DOIs
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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