Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntingdon's disease

Gordon J. Harris, Godfrey D. Pearlson, Carol E. Peyser, Elizabeth H. Aylward, Joy Roberts, Patrick E. Barta, Gary A. Chase, Susan E. Folstein

Research output: Contribution to journalArticle

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Abstract

The characteristic pathological features of Huntington's disease (HD) are neostriatal atrophy and neuronal loss. Although neuroradiological studies often show caudate atrophy in patients with moderate HD, frequently no caudate atrophy is found early in the illness. There have been no quantitative reports to date on in vivo putamen volume measures in mild HD, although the structure is known to be neuropathologically involved in the illness. We measured volumes of caudate nucleus and putamen and bicaudate ratios (BCR) from magnetic resonance images, blind to diagnosis, in 15 patients with mild HD and 19 age- and sex-matched control subjects using a computerized image analysis system. The region showing greatest atrophy was the putamen, which was reduced 50.1% in mean volume in HD patients compared with control subjects (p < 0.000001). In contrast, caudate volume was reduced 27.7% (p = 0.004). BCR was increased 28.5% in HD patients (p = 0.0002). Discriminant function analysis was 94% effective in identifying the diagnostic group based on putamen volume alone, whereas caudate measures had considerable overlap. Correction of putamen volume for head size led to 100% separation by group. Putamen measures and BCR correlated with neurological examination scores but caudate volume did not. Volumetric measurement of putamen is a more sensitive indicator of brain abnormalities in mild HD than measures of caudate atrophy.

Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalAnnals of Neurology
Volume31
Issue number1
StatePublished - Jan 1 1992

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Putamen
Huntington Disease
Magnetic Resonance Imaging
Atrophy
Caudate Nucleus
Neurologic Examination
Discriminant Analysis
Magnetic Resonance Spectroscopy
Head
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Harris, G. J., Pearlson, G. D., Peyser, C. E., Aylward, E. H., Roberts, J., Barta, P. E., ... Folstein, S. E. (1992). Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntingdon's disease. Annals of Neurology, 31(1), 69-75.

Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntingdon's disease. / Harris, Gordon J.; Pearlson, Godfrey D.; Peyser, Carol E.; Aylward, Elizabeth H.; Roberts, Joy; Barta, Patrick E.; Chase, Gary A.; Folstein, Susan E.

In: Annals of Neurology, Vol. 31, No. 1, 01.01.1992, p. 69-75.

Research output: Contribution to journalArticle

Harris, GJ, Pearlson, GD, Peyser, CE, Aylward, EH, Roberts, J, Barta, PE, Chase, GA & Folstein, SE 1992, 'Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntingdon's disease', Annals of Neurology, vol. 31, no. 1, pp. 69-75.
Harris GJ, Pearlson GD, Peyser CE, Aylward EH, Roberts J, Barta PE et al. Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntingdon's disease. Annals of Neurology. 1992 Jan 1;31(1):69-75.
Harris, Gordon J. ; Pearlson, Godfrey D. ; Peyser, Carol E. ; Aylward, Elizabeth H. ; Roberts, Joy ; Barta, Patrick E. ; Chase, Gary A. ; Folstein, Susan E. / Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntingdon's disease. In: Annals of Neurology. 1992 ; Vol. 31, No. 1. pp. 69-75.
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