Purpura fulminans associated with streptococcus pneumoniae septicemia in an asplenic pediatric patient

S. Konda, D. Zell, C. Milikowski, J. Alonso-Llamazares

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Purpura fulminans is a rapidly progressive syndrome of small-vessel thrombosis and hemorrhagic necrosis of the skin accompanied by disseminated intravascular coagulation. We describe a case of Streptococcus pneumoniae septicemia in an asplenic 5-year-old boy on oral tacrolimus, with a past medical history of multivisceral organ transplantation and subsequent development of purpura fulminans on his chest and distal extremities. The acute infectious form of purpura fulminans is usually caused by gram-negative bacteria. Cases secondary to gram-positive encapsulated bacteria usually occur when individuals are immuno-suppressed or have anatomic or functional asplenia. Our patient had both, which likely increased his susceptibility, and he responded well to antimicrobial therapy in addition to prophylactic coverage in the setting of his immunosuppression. We review the literature for similar cases due to S. pneumoniae in the pediatric population and discuss the etiology and treatment of purpura fulminans.

Original languageEnglish (US)
Pages (from-to)623-627
Number of pages5
JournalActas Dermo-Sifiliograficas
Volume104
Issue number7
DOIs
StatePublished - Sep 1 2013

Keywords

  • Asplenia
  • Disseminated intravascular coagulation
  • Hemorrhagic necrosis
  • Immunosuppression
  • Purpura fulminans
  • Sepsis
  • Streptococcus pneumoniae
  • Thrombosis

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine
  • Histology

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