Purine nucleoside kinases in mouse tissues and human lymphoid cells in culture

1. 1. Purine nucleoside kinase activities (adenosine kinase, deoxyadenosine kinase and arabinosyl adenine kinase) in mouse tissues were in the following order: liver > kidney > heart > lung > brain > spleen > intestine. 2. 2. Ratios of deoxyadenosine or arabinosyl adenine kinase to adenosine kinase were significantly higher (10-200 fold) in human lymphoid cells than in mouse tissues. 3. 3. Leukocytes from T-cell acute lymphoblastic leukemic patients had 5-20 fold elevated adenosine deaminase as compared to normal T-cells.