Purification of Growth Hormone-Releasing Factor from Beef Hypothalamus

Andrew V. Schally, Akihiro Kuroshima, Yuichi Ishida, Akira Arimura, Takashige Saito, Cyril Y. Bowers, Sanford L. Steelman

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Potent preparations of growth hormone-releasing factor (GRF) were prepared from bovine hypothalamic extracts, by the glacial acetic acid concentration procedure followed by gel filtration on Sephadex. Purified GRF is distinct from vasopressin, oxy-tocin, a-MSH and other hypothalamic-releasing factors. We are grateful to Dr. E. Müller for advice on the use of his GRF assay and to Dr. William Locke for help in preparation of the manuscript.

Original languageEnglish (US)
Pages (from-to)821-823
Number of pages3
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number3
StatePublished - Jul 1966
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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