Pulseless (Takayasu) disease with ophthalmic manifestations

James R. Lewis, Joel S. Glaser, Norman J. Schatz, Duane G. Hutson

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Pulseless disease (PD) is a rare disorder in which inflammation of the aorta and its major branches leads to stenosis or occlusion of these arteries. It mainly affects young Oriental women, who suffer chronic ischemic injury to tissues of the brain, orbits, upper limbs, myocardium, and kidneys. The ophthalmologic features of pulseless disease tend to be late manifestations, and can include ischemia of the retina, choroid, and anterior segment. The inflammatory process may be reversed in early stages with systemic corticosteroids, but, more frequently, significant arterial stenosis necessitates arterial bypass surgery. A 59-year-old Caucasian woman with stenosis of all four major cervical arteries presented with recurrent blurred vision, syncope, mental obtundation, and a remarkable funduscopic appearance due to bilateral orbital hypoperfusion. Her acute symptoms improved slightly on high-dose systemic corticosteroids, and then resolved completely following arterial bypass surgery.

Original languageEnglish (US)
Pages (from-to)242-249
Number of pages8
JournalJournal of Clinical Neuro-Ophthalmology
Volume13
Issue number4
StatePublished - Dec 1993

Keywords

  • Anastomosis
  • Carotid stenosis
  • Ocular ischemia
  • Pulseless disease

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology

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    Lewis, J. R., Glaser, J. S., Schatz, N. J., & Hutson, D. G. (1993). Pulseless (Takayasu) disease with ophthalmic manifestations. Journal of Clinical Neuro-Ophthalmology, 13(4), 242-249.